close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ygiBPutative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC76073.1); Blastp hit to AAC76073.1 (234 aa), 96% identity in aa 12 - 234; Belongs to the UPF0441 family. (223 aa)    
Predicted Functional Partners:
ygiC
Putative glutathionylspermidine synthase; Similar to E. coli putative synthetase/amidase (AAC76074.1); Blastp hit to AAC76074.1 (386 aa), 94% identity in aa 1 - 386.
 
  
 0.996
yjfC
Putative glutathionylspermidine synthase; Similar to E. coli putative synthetase/amidase (AAC77143.1); Blastp hit to AAC77143.1 (387 aa), 89% identity in aa 1 - 387.
 
  
 0.980
yjfL
Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC77141.1); Blastp hit to AAC77141.1 (132 aa), 90% identity in aa 1 - 132.
 
    0.671
nlpB
Lipoprotein-34; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
  
    0.665
gsp
Bifunctional; similar to E. coli glutathionylspermidine synthetase/amidase (AAC76024.1); Blastp hit to AAC76024.1 (619 aa), 90% identity in aa 1 - 618; glutathionylspermidine amidase.
 
    0.624
wecF-2
Putative inner membrane protein; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis; Belongs to the glycosyltransferase 56 family.
  
     0.550
wzxE
O-antigen translocase in LPS biosyntesis; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA); Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family.
  
     0.532
envZ
Sensory histidine kinase in two-component regulatory system with OmpR; Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes (By similarity). EnvZ functions as a membrane- associated protein kinase that phosphorylates OmpR in response to environmental signals; at low osmolarity OmpR activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription (By similarity).
  
     0.505
pspB
Phage shock protein; Regulatory gene; activates expression of psp operon with PspC; similar to E. coli phage shock protein (AAC74387.1); Blastp hit to AAC74387.1 (74 aa), 89% identity in aa 1 - 74.
  
     0.495
tolC
Outer membrane channel; Specific tolerance to colicin E1; segregation of daughter chromosomes; role in organic solvent tolerance; similar to E. coli outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (AAC76071.1); Blastp hit to AAC76071.1 (495 aa), 89% identity in aa 1 - 495.
  
    0.484
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.