Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ygiMPutative SH3 domain protein; Similar to E. coli orf, hypothetical protein (AAC76091.1); Blastp hit to AAC76091.1 (206 aa), 91% identity in aa 1 - 206. (204 aa)    
Predicted Functional Partners:
cca
tRNA nucleotidyl transferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
 
  
 0.940
ybhP
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73877.1); Blastp hit to AAC73877.1 (253 aa), 86% identity in aa 1 - 253.
      
 0.860
yicJ
Putative GPH family transport protein; Similar to E. coli putative permease (AAC76681.1); Blastp hit to AAC76681.1 (479 aa), 91% identity in aa 20 - 479.
      
 0.856
rseA
Anti sigma E (sigma 24) factor, negative regulator; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytop [...]
  
  
 0.840
STM1676
Putative aldo/keto reductase family; Similar to E. coli orf, hypothetical protein (AAC76048.1); Blastp hit to AAC76048.1 (236 aa), 41% identity in aa 2 - 224.
      
 0.751
perM
Similar to E. coli putative permease (AAC75546.1); Blastp hit to AAC75546.1 (353 aa), 94% identity in aa 1 - 350.
      
 0.719
yjaG
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC76973.1); Blastp hit to AAC76973.1 (196 aa), 94% identity in aa 1 - 196; To H.influenzae HI_0431.
  
    0.668
ytfN
Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC77178.1); Blastp hit to AAC77178.1 (1259 aa), 86% identity in aa 1 - 1259.
 
     0.597
yecG
Putative universal stress protein; Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family.
 
    0.593
ygiF
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC76090.1); Blastp hit to AAC76090.1 (433 aa), 85% identity in aa 1 - 433.
       0.582
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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