node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
bacA | folB | STM3205 | STM3206 | Bacitracin resistance; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.611 |
bacA | ksgA | STM3205 | STM0090 | Bacitracin resistance; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.668 |
bacA | mdfA | STM3205 | STM0866 | Bacitracin resistance; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | Multidrug translocase; Similar to E. coli proton motive force efflux pump (AAC73929.1); Blastp hit to AAC73929.1 (410 aa), 90% identity in aa 1 - 406. | 0.628 |
bacA | mraY | STM3205 | STM0125 | Bacitracin resistance; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | phospho-N-acetylmuramoyl-pentapeptide transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | 0.931 |
bacA | murA | STM3205 | STM3307 | Bacitracin resistance; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.691 |
bacA | murE | STM3205 | STM0123 | Bacitracin resistance; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.656 |
bacA | pgpB | STM3205 | STM1710 | Bacitracin resistance; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | Similar to E. coli non-essential phosphatidylglycerophosphate phosphatase, membrane bound (AAC74360.1); Blastp hit to AAC74360.1 (254 aa), 82% identity in aa 1 - 254. | 0.646 |
bacA | uppS | STM3205 | STM0221 | Bacitracin resistance; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | Undecaprenyl pyrophosphate synthetase (di-trans, poly-cis-decaprenylcistransferase); Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.968 |
bacA | ybjG | STM3205 | STM0865 | Bacitracin resistance; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | Putative permease; Similar to E. coli orf, hypothetical protein (AAC73928.1); Blastp hit to AAC73928.1 (198 aa), 78% identity in aa 1 - 198. | 0.973 |
bacA | ybjZ | STM3205 | STM0942 | Bacitracin resistance; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | Putative ABC superfamily (atp&memb) transport protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.634 |
folB | bacA | STM3206 | STM3205 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Bacitracin resistance; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.611 |
ksgA | bacA | STM0090 | STM3205 | S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | Bacitracin resistance; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.668 |
ksgA | ybjZ | STM0090 | STM0942 | S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | Putative ABC superfamily (atp&memb) transport protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.702 |
mdfA | bacA | STM0866 | STM3205 | Multidrug translocase; Similar to E. coli proton motive force efflux pump (AAC73929.1); Blastp hit to AAC73929.1 (410 aa), 90% identity in aa 1 - 406. | Bacitracin resistance; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.628 |
mdfA | ybjG | STM0866 | STM0865 | Multidrug translocase; Similar to E. coli proton motive force efflux pump (AAC73929.1); Blastp hit to AAC73929.1 (410 aa), 90% identity in aa 1 - 406. | Putative permease; Similar to E. coli orf, hypothetical protein (AAC73928.1); Blastp hit to AAC73928.1 (198 aa), 78% identity in aa 1 - 198. | 0.794 |
mdfA | ybjZ | STM0866 | STM0942 | Multidrug translocase; Similar to E. coli proton motive force efflux pump (AAC73929.1); Blastp hit to AAC73929.1 (410 aa), 90% identity in aa 1 - 406. | Putative ABC superfamily (atp&memb) transport protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.810 |
mraY | bacA | STM0125 | STM3205 | phospho-N-acetylmuramoyl-pentapeptide transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | Bacitracin resistance; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.931 |
mraY | murA | STM0125 | STM3307 | phospho-N-acetylmuramoyl-pentapeptide transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.822 |
mraY | murE | STM0125 | STM0123 | phospho-N-acetylmuramoyl-pentapeptide transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.985 |
mraY | uppS | STM0125 | STM0221 | phospho-N-acetylmuramoyl-pentapeptide transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | Undecaprenyl pyrophosphate synthetase (di-trans, poly-cis-decaprenylcistransferase); Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.601 |