Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
gene fusions
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[Homology]
Score
yqjBPutative outer membrane protein; Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR. (127 aa)    
Predicted Functional Partners:
envZ
Sensory histidine kinase in two-component regulatory system with OmpR; Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes (By similarity). EnvZ functions as a membrane- associated protein kinase that phosphorylates OmpR in response to environmental signals; at low osmolarity OmpR activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription (By similarity).
    
 0.985
yqjA
Putative DedA family membrane protein; Similar to E. coli orf, hypothetical protein (AAC76130.1); Blastp hit to AAC76130.1 (220 aa), 95% identity in aa 1 - 220.
  
  
 0.927
cpxA
Sensory kinase in two-component regulatory system with CpxR; Senses misfolded proteins in bacterial envelope; similar to E. coli probable sensor protein (histidine protein kinase), acting on arcA (AAC76893.1); Blastp hit to AAC76893.1 (457 aa), 96% identity in aa 1 - 457.
    
 
 0.741
ompR
Response regulator in two-component regulatory system with EnvZ; Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes (By similarity). Plays a central role in both acid and osmotic stress responses. Binds to the promoter of both ompC and ompF; at low osmolarity it activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription (By similarity).
      
 0.727
cpxR
Response reguator in two-component regulatory system with CpxA; Regulates expression of protein folding and degrading factors (OmpR family); similar to E. coli transcriptional regulator in 2-component system (AAC76894.1); Blastp hit to AAC76894.1 (232 aa), 97% identity in aa 1 - 232.
   
  
 0.724
ompC
Outer membrane protein 1b (ib;c); Forms pores that allow passive diffusion of small molecules across the outer membrane.
      
 0.579
yqjC
Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC76132.1); Blastp hit to AAC76132.1 (127 aa), 84% identity in aa 6 - 127.
  
    0.534
yqjE
Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC76134.1); Blastp hit to AAC76134.1 (134 aa), 89% identity in aa 1 - 130.
  
    0.521
yqjK
Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC76135.1); Blastp hit to AAC76135.1 (99 aa), 87% identity in aa 1 - 99.
  
    0.521
yqjD
Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC76133.1); Blastp hit to AAC76133.1 (101 aa), 90% identity in aa 1 - 101.
  
    0.470
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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