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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yrbGPutative CacA family Na:Ca transport protein; Similar to E. coli orf, hypothetical protein (AAC76228.1); Blastp hit to AAC76228.1 (325 aa), 87% identity in aa 1 - 324. (325 aa)    
Predicted Functional Partners:
yrbI
Putative protein of HAD superfamily; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family.
    
 0.968
yrbH
Putative polysialic acid capsule expression protein; Involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs). Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P) (By similarity).
 
  
 0.963
yhbG
Putative ABC superfamily transport protein; Atp_bind; similar to E. coli putative ATP-binding component of a transport system (AAC76233.1); Blastp hit to AAC76233.1 (241 aa), 98% identity in aa 1 - 241.
     
 0.931
yrbK
Putative inner membrane protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family.
     
 0.911
yhbH
Putative sigma N modulation factor; During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes.
     
 0.876
yhbN
Putative ABC superfamily transport protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.
     
 0.832
rpoN
Sigma N factor of RNA polymerase; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of enzymes involved in arginine catabolism. The open complex (sigma-54 and core RNA polymerase) serves as the receptor for the receipt of the melting signal from the remotely bound activator protein GlnG(NtrC).
     
 0.809
chaA
Similar to E. coli sodium-calcium/proton antiporter (AAC74300.1); Blastp hit to AAC74300.1 (366 aa), 93% identity in aa 1 - 366.
   
  
 0.737
ptsN
Sugar specific PTS family enzyme IIA; Also regulates N metabolism; similar to E. coli phosphotransferase system enzyme IIA, regulates N metabolism (AAC76236.1); Blastp hit to AAC76236.1 (163 aa), 95% identity in aa 1 - 163.
     
 0.725
ptsO
Phosphocarrier protein HPr-like NPr; Nitrogen related; exchanges phosphate with Enzyme I; similar to E. coli phosphocarrier protein HPr-like NPr, nitrogen related, exchanges phosphate with Enzyme I, Hpr (AAC76238.1); Blastp hit to AAC76238.1 (90 aa), 96% identity in aa 1 - 90.
     
 0.708
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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