STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yhdEPutative inhibitor of septum formation; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (197 aa)    
Predicted Functional Partners:
mreD
Rod shape-determining protein; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family.
 
  
 0.948
cafA
RNase G; Similar to E. coli bundles of cytoplasmic filaments (AAC76279.1); Blastp hit to AAC76279.1 (495 aa), 96% identity in aa 7 - 495.
 
    0.909
yhgF
Putative RNase R; Similar to E. coli orf, hypothetical protein (AAC76432.1); Blastp hit to AAC76432.1 (740 aa), 94% identity in aa 1 - 740.
      
 0.897
yjgA
Similar to E. coli putative alpha helix protein (AAC77191.1); Blastp hit to AAC77191.1 (183 aa), 95% identity in aa 1 - 183; Belongs to the UPF0307 family.
   
  
 0.894
mreC
Rod shape-determining protein; Involved in formation and maintenance of cell shape.
  
  
 0.893
yhdP
Putative protease; Similar to E. coli orf, hypothetical protein (AAC76277.1); Blastp hit to AAC76277.1 (986 aa), 80% identity in aa 1 - 986.
 
    0.828
yggS
Putative enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.
    0.759
radC
Putative DNA repair protein; Associated with replication forks; similar to E. coli DNA repair protein (AAC76662.1); Blastp hit to AAC76662.1 (224 aa), 83% identity in aa 10 - 224; Belongs to the UPF0758 family. YicR subfamily.
 
  
 0.748
yeeX
Similar to E. coli putative alpha helix protein (AAC75068.1); Blastp hit to AAC75068.1 (131 aa), 93% identity in aa 23 - 131; Belongs to the UPF0265 family.
      
 0.716
mreB
Rod shape-determining protein; Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
  
  
 0.714
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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