| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| crp | fis | STM3466 | STM3385 | Catabolite activator protein (CAP); A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity). | Site-specific DNA inversion stimulation factor; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | 0.925 |
| crp | lrp | STM3466 | STM0959 | Catabolite activator protein (CAP); A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity). | Regulator for lrp regulon and high-affinity branched-chain amino acid transport system; Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes. | 0.904 |
| crp | rpoS | STM3466 | STM2924 | Catabolite activator protein (CAP); A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity). | Sigma S (sigma 38) factor of RNA polymerase; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. | 0.931 |
| fis | crp | STM3385 | STM3466 | Site-specific DNA inversion stimulation factor; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | Catabolite activator protein (CAP); A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity). | 0.925 |
| fis | hha | STM3385 | STM0473 | Site-specific DNA inversion stimulation factor; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | Hemolysin expression modulating protein (involved in environmental regulation of virulence factors); Interacts with H-NS and in this complex might contact DNA, which could provide an additional surface for DNA binding to the H-NS- Hha complex; may not bind DNA in the absence of H-NS. In vitro improves the ability of H-NS to bind DNA under a precise set of conditions. | 0.809 |
| fis | himD | STM3385 | STM0982 | Site-specific DNA inversion stimulation factor; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | Integration host factor (IHF), beta subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | 0.785 |
| fis | lrp | STM3385 | STM0959 | Site-specific DNA inversion stimulation factor; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | Regulator for lrp regulon and high-affinity branched-chain amino acid transport system; Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes. | 0.733 |
| fis | panF | STM3385 | STM3382 | Site-specific DNA inversion stimulation factor; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | Similar to E. coli sodium/pantothenate symporter (AAC76290.1); Blastp hit to AAC76290.1 (485 aa), 93% identity in aa 3 - 485; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.770 |
| fis | prmA | STM3385 | STM3383 | Site-specific DNA inversion stimulation factor; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | Methylation of 50S ribosomal subunit protein L11; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. | 0.832 |
| fis | rpoS | STM3385 | STM2924 | Site-specific DNA inversion stimulation factor; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | Sigma S (sigma 38) factor of RNA polymerase; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. | 0.775 |
| fis | typA | STM3385 | STM4009 | Site-specific DNA inversion stimulation factor; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | GTP-binding elongation factor family protein; A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA (By similarity). A ribosome-stimulated GTPase, GTPase activity increases 4 fold in the presence of 70S ribosomes. Bind to 70S ribosomes in the presence of GTP or its non- hydrolyzable analog [...] | 0.817 |
| fis | yhdG | STM3385 | STM3384 | Site-specific DNA inversion stimulation factor; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | Putative TIM-barrel enzyme; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. | 0.998 |
| fis | yhdT | STM3385 | STM3381 | Site-specific DNA inversion stimulation factor; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC76289.1); Blastp hit to AAC76289.1 (80 aa), 82% identity in aa 1 - 80. | 0.769 |
| hha | fis | STM0473 | STM3385 | Hemolysin expression modulating protein (involved in environmental regulation of virulence factors); Interacts with H-NS and in this complex might contact DNA, which could provide an additional surface for DNA binding to the H-NS- Hha complex; may not bind DNA in the absence of H-NS. In vitro improves the ability of H-NS to bind DNA under a precise set of conditions. | Site-specific DNA inversion stimulation factor; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | 0.809 |
| hha | typA | STM0473 | STM4009 | Hemolysin expression modulating protein (involved in environmental regulation of virulence factors); Interacts with H-NS and in this complex might contact DNA, which could provide an additional surface for DNA binding to the H-NS- Hha complex; may not bind DNA in the absence of H-NS. In vitro improves the ability of H-NS to bind DNA under a precise set of conditions. | GTP-binding elongation factor family protein; A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA (By similarity). A ribosome-stimulated GTPase, GTPase activity increases 4 fold in the presence of 70S ribosomes. Bind to 70S ribosomes in the presence of GTP or its non- hydrolyzable analog [...] | 0.498 |
| himD | fis | STM0982 | STM3385 | Integration host factor (IHF), beta subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | Site-specific DNA inversion stimulation factor; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | 0.785 |
| himD | lrp | STM0982 | STM0959 | Integration host factor (IHF), beta subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | Regulator for lrp regulon and high-affinity branched-chain amino acid transport system; Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes. | 0.497 |
| himD | rpoS | STM0982 | STM2924 | Integration host factor (IHF), beta subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | Sigma S (sigma 38) factor of RNA polymerase; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. | 0.415 |
| lrp | crp | STM0959 | STM3466 | Regulator for lrp regulon and high-affinity branched-chain amino acid transport system; Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes. | Catabolite activator protein (CAP); A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity). | 0.904 |
| lrp | fis | STM0959 | STM3385 | Regulator for lrp regulon and high-affinity branched-chain amino acid transport system; Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes. | Site-specific DNA inversion stimulation factor; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. | 0.733 |