Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
slyXPutative cytoplasmic protein; Similar to E. coli host factor for lysis of phiX174 infection (AAC76373.1); Blastp hit to AAC76373.1 (72 aa), 94% identity in aa 1 - 72; Belongs to the SlyX family. (72 aa)    
Predicted Functional Partners:
corE
Putative cytochrome c-type biogenesis protein; Heme exporter protein C; CorE (gi|4877800).
  
   
 0.886
ycgN
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC74265.1); Blastp hit to AAC74265.1 (158 aa), 92% identity in aa 6 - 158; Belongs to the UPF0260 family.
     
 0.862
yejK
Nucleotide associated protein; Present in spermidine nucleoids; similar to E. coli orf, hypothetical protein (AAC75247.1); Blastp hit to AAC75247.1 (335 aa), 96% identity in aa 1 - 334.
  
   
 0.740
yciS
Putative inner membrane protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family.
  
     0.726
yqaB
Similar to E. coli putative phosphatase (AAC75737.1); Blastp hit to AAC75737.1 (188 aa), 87% identity in aa 1 - 188.
      
 0.726
dsbB
Putative disulfide oxidoreductase; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by oxidizing the DsbA protein (By similarity); Belongs to the DsbB family.
  
   
 0.711
yihI
Putative cytoplasmic protein; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family.
  
    0.692
yfbV
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75355.1); Blastp hit to AAC75355.1 (151 aa), 95% identity in aa 1 - 151.
  
    0.670
yjgD
Putative cytoplasmic protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
  
  
 0.661
rseA
Anti sigma E (sigma 24) factor, negative regulator; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytop [...]
  
     0.655
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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