Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nirCFNT family nitrite transport protein; Catalyzes nitrite uptake and nitrite export across the cytoplasmic membrane; Belongs to the FNT transporter (TC 2.A.44) family. (269 aa)    
Predicted Functional Partners:
cysG
Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
  
 0.990
nirD
Nitrite reductase small subunit; Required for activity of the reductase.
 
  
 0.973
nirB
Similar to E. coli nitrite reductase (NAD(P)H) subunit (AAC76390.1); Blastp hit to AAC76390.1 (847 aa), 95% identity in aa 1 - 847; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.952
yfdC
Similar to E. coli putative transport (AAC75407.1); Blastp hit to AAC75407.1 (310 aa), 87% identity in aa 1 - 304.
      
 0.856
narK
Similar to E. coli nitrite extrusion protein (AAC74307.1); Blastp hit to AAC74307.1 (463 aa), 94% identity in aa 1 - 462.
  
  
 0.752
yhfL
Putative outer membrane lipoprotein; Similar to E. coli orf, hypothetical protein (AAC76394.1); Blastp hit to AAC76394.1 (55 aa), 81% identity in aa 1 - 54.
     
 0.691
narU
MFS superfamily nitrate extrusion protein; Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane; Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
     
 0.679
yggL
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75996.1); Blastp hit to AAC75996.1 (118 aa), 95% identity in aa 11 - 118.
      
 0.679
nrfE
Formate-dependent nitrite reductase; Possible subunit of a heme lyase.
   
  
 0.615
yadF
Putative carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family.
  
    0.590
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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