| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| STM2730 | dam | STM2730 | STM3484 | Fels-2 prophage protein; Similar to retron in E coli; similar to E. coli DNA adenine methylase (AAC76412.1); Blastp hit to AAC76412.1 (278 aa), 46% identity in aa 8 - 266. | DNA adenine methylase; Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication; Belongs to the N(4)/N(6)-methyltransferase family. | 0.907 |
| STM2730 | dcm | STM2730 | STM1992 | Fels-2 prophage protein; Similar to retron in E coli; similar to E. coli DNA adenine methylase (AAC76412.1); Blastp hit to AAC76412.1 (278 aa), 46% identity in aa 8 - 266. | Similar to E. coli DNA cytosine methylase (AAC75027.1); Blastp hit to AAC75027.1 (472 aa), 83% identity in aa 1 - 472. | 0.554 |
| STM2730 | metJ | STM2730 | STM4099 | Fels-2 prophage protein; Similar to retron in E coli; similar to E. coli DNA adenine methylase (AAC76412.1); Blastp hit to AAC76412.1 (278 aa), 46% identity in aa 8 - 266. | Transcriptional repressor of all met genes but metF; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated (By similarity); Belongs to the MetJ family. | 0.526 |
| STM2730 | mutH | STM2730 | STM3005 | Fels-2 prophage protein; Similar to retron in E coli; similar to E. coli DNA adenine methylase (AAC76412.1); Blastp hit to AAC76412.1 (278 aa), 46% identity in aa 8 - 266. | Methyl-directed mismatch repair protein; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair; Belongs to the MutH family. | 0.908 |
| STM2730 | seqA | STM2730 | STM0697 | Fels-2 prophage protein; Similar to retron in E coli; similar to E. coli DNA adenine methylase (AAC76412.1); Blastp hit to AAC76412.1 (278 aa), 46% identity in aa 8 - 266. | Negative modulator of initiation of replication; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.647 |
| aroB | dam | STM3486 | STM3484 | Dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | DNA adenine methylase; Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication; Belongs to the N(4)/N(6)-methyltransferase family. | 0.746 |
| aroB | damX | STM3486 | STM3485 | Dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Membrane protein; Non-essential cell division protein. | 0.821 |
| aroB | gph | STM3486 | STM3482 | Dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. | 0.648 |
| aroB | rpe | STM3486 | STM3483 | Dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Similar to E. coli D-ribulose-5-phosphate 3-epimerase (AAC76411.1); Blastp hit to AAC76411.1 (225 aa), 97% identity in aa 1 - 224; Belongs to the ribulose-phosphate 3-epimerase family. | 0.488 |
| aroB | trpS | STM3486 | STM3481 | Dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Tryptophan tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.537 |
| dam | STM2730 | STM3484 | STM2730 | DNA adenine methylase; Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication; Belongs to the N(4)/N(6)-methyltransferase family. | Fels-2 prophage protein; Similar to retron in E coli; similar to E. coli DNA adenine methylase (AAC76412.1); Blastp hit to AAC76412.1 (278 aa), 46% identity in aa 8 - 266. | 0.907 |
| dam | aroB | STM3484 | STM3486 | DNA adenine methylase; Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication; Belongs to the N(4)/N(6)-methyltransferase family. | Dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.746 |
| dam | damX | STM3484 | STM3485 | DNA adenine methylase; Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication; Belongs to the N(4)/N(6)-methyltransferase family. | Membrane protein; Non-essential cell division protein. | 0.522 |
| dam | dcm | STM3484 | STM1992 | DNA adenine methylase; Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication; Belongs to the N(4)/N(6)-methyltransferase family. | Similar to E. coli DNA cytosine methylase (AAC75027.1); Blastp hit to AAC75027.1 (472 aa), 83% identity in aa 1 - 472. | 0.759 |
| dam | gph | STM3484 | STM3482 | DNA adenine methylase; Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication; Belongs to the N(4)/N(6)-methyltransferase family. | Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. | 0.922 |
| dam | metJ | STM3484 | STM4099 | DNA adenine methylase; Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication; Belongs to the N(4)/N(6)-methyltransferase family. | Transcriptional repressor of all met genes but metF; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated (By similarity); Belongs to the MetJ family. | 0.650 |
| dam | mutH | STM3484 | STM3005 | DNA adenine methylase; Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication; Belongs to the N(4)/N(6)-methyltransferase family. | Methyl-directed mismatch repair protein; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair; Belongs to the MutH family. | 0.921 |
| dam | rpe | STM3484 | STM3483 | DNA adenine methylase; Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication; Belongs to the N(4)/N(6)-methyltransferase family. | Similar to E. coli D-ribulose-5-phosphate 3-epimerase (AAC76411.1); Blastp hit to AAC76411.1 (225 aa), 97% identity in aa 1 - 224; Belongs to the ribulose-phosphate 3-epimerase family. | 0.900 |
| dam | seqA | STM3484 | STM0697 | DNA adenine methylase; Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication; Belongs to the N(4)/N(6)-methyltransferase family. | Negative modulator of initiation of replication; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.679 |
| dam | trpS | STM3484 | STM3481 | DNA adenine methylase; Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication; Belongs to the N(4)/N(6)-methyltransferase family. | Tryptophan tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.884 |
