STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mrcASimilar to E. coli peptidoglycan synthetase; penicillin-binding protein 1A (AAC76421.1); Blastp hit to AAC76421.1 (858 aa), 92% identity in aa 1 - 858. (858 aa)    
Predicted Functional Partners:
dacA
Similar to E. coli D-alanyl-D-alanine carboxypeptidase, fraction A; penicillin-binding protein 5 (AAC73733.1); Blastp hit to AAC73733.1 (403 aa), 95% identity in aa 1 - 403; Belongs to the peptidase S11 family.
   
 
 0.968
dacC
Similar to E. coli D-alanyl-D-alanine carboxypeptidase; penicillin-binding protein 6 (AAC73926.1); Blastp hit to AAC73926.1 (400 aa), 92% identity in aa 1 - 400; Belongs to the peptidase S11 family.
     
 0.967
mrcB
Transpeptidase of penicillin-binding protein 1b; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits).
 
0.961
dacD
DD-carboxypeptidase; Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; Belongs to the peptidase S11 family.
   
 
 0.943
pbpC
Transglycosylase of penicillin-binding protein 1c; Similar to E. coli putative peptidoglycan enzyme (AAC75572.1); Blastp hit to AAC75572.1 (770 aa), 82% identity in aa 7 - 767.
  
 
0.926
ftsI-2
Putative penicillin-binding protein-3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
  
 
 
 0.875
murA
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.
  
  
 0.871
yraM
Putative transglycosylase; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Belongs to the LpoA family.
  
 
 
 0.865
mrdA-2
Putative penicillin-binding protein; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily.
  
 
 
 0.845
ftsI
Division specific transpeptidase; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
  
 
 
 0.841
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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