| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| gmk | guaA | STM3740 | STM2510 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | 0.978 |
| gmk | guaB | STM3740 | STM2511 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.893 |
| gmk | guaC | STM3740 | STM0141 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.953 |
| gmk | nagD | STM3740 | STM0681 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Similar to E. coli N-acetylglucosamine metabolism (AAC73769.1); Blastp hit to AAC73769.1 (250 aa), 96% identity in aa 1 - 250. | 0.900 |
| gmk | surE | STM3740 | STM2927 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Survival protein, protein damage control; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. | 0.917 |
| gmk | yrfG | STM3740 | STM3496 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Similar to E. coli putative phosphatase (AAC76424.1); Blastp hit to AAC76424.1 (237 aa), 85% identity in aa 16 - 237. | 0.905 |
| guaA | gmk | STM2510 | STM3740 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.978 |
| guaA | guaB | STM2510 | STM2511 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
| guaA | guaC | STM2510 | STM0141 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.993 |
| guaA | nagD | STM2510 | STM0681 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Similar to E. coli N-acetylglucosamine metabolism (AAC73769.1); Blastp hit to AAC73769.1 (250 aa), 96% identity in aa 1 - 250. | 0.927 |
| guaA | surE | STM2510 | STM2927 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Survival protein, protein damage control; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. | 0.963 |
| guaA | xapA | STM2510 | STM2422 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Xanthosine phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.626 |
| guaA | yrfG | STM2510 | STM3496 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Similar to E. coli putative phosphatase (AAC76424.1); Blastp hit to AAC76424.1 (237 aa), 85% identity in aa 16 - 237. | 0.909 |
| guaB | gmk | STM2511 | STM3740 | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.893 |
| guaB | guaA | STM2511 | STM2510 | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | 0.999 |
| guaB | guaC | STM2511 | STM0141 | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.950 |
| guaB | nagD | STM2511 | STM0681 | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Similar to E. coli N-acetylglucosamine metabolism (AAC73769.1); Blastp hit to AAC73769.1 (250 aa), 96% identity in aa 1 - 250. | 0.906 |
| guaB | surE | STM2511 | STM2927 | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Survival protein, protein damage control; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. | 0.949 |
| guaB | xapA | STM2511 | STM2422 | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Xanthosine phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.434 |
| guaB | yrfG | STM2511 | STM3496 | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Similar to E. coli putative phosphatase (AAC76424.1); Blastp hit to AAC76424.1 (237 aa), 85% identity in aa 16 - 237. | 0.916 |
