STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rtcRSigma N (sigma 54)-dependent regulator of rtcBA expression; EBP family; similar to E. coli putative 2-component regulator (AAC76447.1); Blastp hit to AAC76447.1 (532 aa), 84% identity in aa 1 - 527. (527 aa)    
Predicted Functional Partners:
rtcA
RNA 3'-terminal phosphate cyclase (with b3419); Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
 
  
 0.992
rtcB
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC76446.1); Blastp hit to AAC76446.1 (408 aa), 87% identity in aa 1 - 408.
 
  
 0.988
STM3521
Putative ribonucleoprotein related-protein.
 
   
 0.937
STM3517
Putative DNA-damage-inducibile protein; Resembles dinJ; similar to E. coli damage-inducible protein J (AAC73330.1); Blastp hit to AAC73330.1 (86 aa), 83% identity in aa 1 - 86.
   
  
 0.771
yhbQ
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC76189.1); Blastp hit to AAC76189.1 (100 aa), 81% identity in aa 1 - 100; Belongs to the UPF0213 family.
      
 0.698
STM0292
Putative RHS-family protein; Similar to E. coli rhsE protein in rhs element (AAC74538.1); Blastp hit to AAC74538.1 (682 aa), 44% identity in aa 426 - 541, 28% identity in aa 273 - 300.
  
     0.594
rpoN
Sigma N factor of RNA polymerase; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of enzymes involved in arginine catabolism. The open complex (sigma-54 and core RNA polymerase) serves as the receptor for the receipt of the melting signal from the remotely bound activator protein GlnG(NtrC).
  
   
 0.590
yijF
Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC76926.1); Blastp hit to AAC76926.1 (205 aa), 67% identity in aa 1 - 203.
  
     0.520
yfbK
Putative von Willebrand factor, vWF type A domain protein; Similar to E. coli orf, hypothetical protein (AAC75330.1); Blastp hit to AAC75330.1 (575 aa), 45% identity in aa 22 - 190.
  
    0.490
creD
Similar to E. coli tolerance to colicin E2 (AAC77353.1); Blastp hit to AAC77353.1 (450 aa), 73% identity in aa 1 - 450.
  
     0.478
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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