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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glpRDeoR family; similar to E. coli repressor of the glp operon (AAC76448.1); Blastp hit to AAC76448.1 (252 aa), 93% identity in aa 1 - 252. (252 aa)    
Predicted Functional Partners:
glpG
Protein of glp regulon; Rhomboid-type serine protease that catalyzes intramembrane proteolysis.
 
  
 0.895
glpD
Aerobic; similar to E. coli sn-glycerol-3-phosphate dehydrogenase (aerobic) (AAC76451.1); Blastp hit to AAC76451.1 (501 aa), 90% identity in aa 1 - 501; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
 
  
 0.878
STM3794
Putative deoR family regulatory protein; Similar to E. coli transcriptional repressor for deo operon, tsx, nupG (AAC73927.1); Blastp hit to AAC73927.1 (252 aa), 38% identity in aa 1 - 251.
  
     0.763
glpE
Thiosulfate/cyanide sulfurtransferase; Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
  
  
 0.745
ylbE
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73621.1); Blastp hit to AAC73621.1 (333 aa), 94% identity in aa 1 - 332.
      
 0.700
cytR
GalR/LacI family transcriptional repressor; Similar to E. coli regulator for deo operon, udp, cdd, tsx, nupC, and nupG (AAC76916.1); Blastp hit to AAC76916.1 (341 aa), 86% identity in aa 1 - 341.
      
 0.658
yfeR
Similar to E. coli putative transcriptional regulator LYSR-type (AAC75462.1); Blastp hit to AAC75462.1 (308 aa), 79% identity in aa 1 - 308; Belongs to the LysR transcriptional regulatory family.
      
 0.580
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate.
  
  
 0.572
rph
RNase PH; Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates.
   
  
 0.498
fadR
Negative regulator of fad regulon; Multifunctional regulator of fatty acid metabolism. Represses transcription of at least eight genes required for fatty acid transport and beta-oxidation including fadA, fadB, fadD, fadL and fadE. Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis: fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the glyoxylate shunt enzymes. Binding of FadR is specifically inhibited by long chain fatty acyl-CoA compounds (By similarity).
   
  
 0.470
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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