STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gntKThermoresistant; similar to E. coli gluconokinase 2, thermoresistant (AAC76462.1); Blastp hit to AAC76462.1 (162 aa), 96% identity in aa 1 - 161. (177 aa)    
Predicted Functional Partners:
gnd
Gluconate-6-phosphate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
  
 0.994
edd
6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family.
  
 
 0.988
gntU
Similar to E. coli low-affinity gluconate transport permease protein, interrupted (AAC76461.1); Blastp hit to AAC76461.1 (332 aa), 96% identity in aa 1 - 331.
 
  
 0.983
gntT
GntP family; similar to E. coli high-affinity transport of gluconate / gluconate permease (AAC76440.1); Blastp hit to AAC76440.1 (437 aa), 96% identity in aa 1 - 437.
 
  
 0.910
idnK
Similar to E. coli gluconate kinase, thermosensitive glucokinase (AAC77225.1); Blastp hit to AAC77225.1 (187 aa), 86% identity in aa 1 - 171.
  
  
0.908
yiaE
2-keto-D-gluconate reductase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
    
 0.901
ybhE
Putative 3-carboxymuconate cyclase; Catalyzes the hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate.
     
 0.900
gntR
Transcriptional repressor gnt-I; gntUKR; GalR/LacI family; similar to E. coli regulator of gluconate (gnt) operon (AAC76463.1); Blastp hit to AAC76463.1 (313 aa), 97% identity in aa 1 - 304.
 
 
 0.887
rpiA
Constitutive ribosephosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
    
 0.832
STM0148
Putative cytoplasmic protein; Hypothetical protein (gi|7688348); Belongs to the glycosyl hydrolase 43 family.
   
  
 0.726
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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