STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rbsK-2Putative transcriptional regulator of sugar metabolism; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (404 aa)    
Predicted Functional Partners:
rbsD
D-ribose high-affinity transport system; Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
 
 
 0.952
STM4066
Putative sugar kinase; Ribokinase family; similar to E. coli putative kinase (AAD13445.1); Blastp hit to AAD13445.1 (300 aa), 28% identity in aa 14 - 297; Belongs to the carbohydrate kinase PfkB family.
  
   
 0.941
rbsB
D-ribose transport protein; Part of the ABC transporter complex RbsABC involved in ribose import. Binds ribose.
 
  
 0.888
STM3548
Putative cytoplasmic protein; ORF 245 (gi|4456875).
 
    0.854
rbsR
Transcriptional repressor for rbs operon (GalR/LacI family); Similar to E. coli regulator for rbs operon (AAC76776.1); Blastp hit to AAC76776.1 (330 aa), 89% identity in aa 1 - 329.
  
 0.850
rbsA
D-ribose high-affinity transport protein; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
  
  
 0.748
rbsC
D-ribose high-affinity transport protein (1st module, ATP-binding subunit); ABC superfamily (membrane); similar to E. coli D-ribose high-affinity transport system (AAC76773.1); Blastp hit to AAC76773.1 (321 aa), 96% identity in aa 1 - 321; Belongs to the binding-protein-dependent transport system permease family.
 
  
 0.743
rihC
Putative purine nucleoside hydrolase; Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity.
  
 0.729
STM3549
Putative inner membrane protein.
  
    0.720
STM3550
Similar to E. coli putative hydrolase (AAC76404.1); Blastp hit to AAC76404.1 (292 aa), 28% identity in aa 24 - 289, 71% identity in aa 7 - 20.
 
    0.712
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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