Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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rbsK-2Putative transcriptional regulator of sugar metabolism; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (404 aa)    
Predicted Functional Partners:
STM4066
Putative sugar kinase; Ribokinase family; similar to E. coli putative kinase (AAD13445.1); Blastp hit to AAD13445.1 (300 aa), 28% identity in aa 14 - 297; Belongs to the carbohydrate kinase PfkB family.
  
   
 0.931
rbsD
D-ribose high-affinity transport system; Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
 
 
 0.924
rbsB
D-ribose transport protein; Part of the ABC transporter complex RbsABC involved in ribose import. Binds ribose.
 
  
 0.871
rbsR
Transcriptional repressor for rbs operon (GalR/LacI family); Similar to E. coli regulator for rbs operon (AAC76776.1); Blastp hit to AAC76776.1 (330 aa), 89% identity in aa 1 - 329.
 
  
 0.863
STM3548
Putative cytoplasmic protein; ORF 245 (gi|4456875).
 
    0.858
rihC
Putative purine nucleoside hydrolase; Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity.
 
  
 0.740
STM3549
Putative inner membrane protein.
  
    0.726
STM3550
Similar to E. coli putative hydrolase (AAC76404.1); Blastp hit to AAC76404.1 (292 aa), 28% identity in aa 24 - 289, 71% identity in aa 7 - 20.
 
    0.715
ybeK
Putative purine nucleoside hydrolase; Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively.
 
  
 0.708
rbsC
D-ribose high-affinity transport protein (1st module, ATP-binding subunit); ABC superfamily (membrane); similar to E. coli D-ribose high-affinity transport system (AAC76773.1); Blastp hit to AAC76773.1 (321 aa), 96% identity in aa 1 - 321; Belongs to the binding-protein-dependent transport system permease family.
 
  
 0.667
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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