Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
yhhVPutative cytoplasmic protein; Putative antitoxin component of a toxin-antitoxin (TA) system; its cognate toxin is unknown. (75 aa)    
Predicted Functional Partners:
parE
DNA topoisomerase IV, subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. Belongs to the type II topoisomerase family. ParE type 1 subfamily.
      
 0.899
abrB
Similar to E. coli putative transport protein (AAC73809.1); Blastp hit to AAC73809.1 (363 aa), 80% identity in aa 16 - 361.
      
 0.896
vapC
Putative nucleic acid-binding protein; Toxic component of a type II toxin-antitoxin (TA) system. A site-specific tRNA-(fMet) endonuclease, it cleaves both charged and uncharged tRNA-(fMet) between positions 38 and 39 at the anticodon stem-loop boundary. Does not cleave tRNA(Met), tRNA(Arg2), tRNA(His), tRNA(Leu), tRNA(Phe) tRNA(Thr1), tRNA(Tyr) or tRNA(Val). Overexpression in E.coli inhibits translation, leads to loss of cell growth and degradation of tRNA(fMet), these effects are neutralized by expression of cognate antitoxin VapB. Expression also activates translation initiation at c [...]
     
 0.875
STM3558
Homology to death -on-curing protein of phage P1.
  
  
 0.827
yjgK
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC77209.1); Blastp hit to AAC77209.1 (153 aa), 80% identity in aa 4 - 153.
      
 0.769
ybaJ
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73563.1); Blastp hit to AAC73563.1 (124 aa), 95% identity in aa 1 - 124.
      
 0.766
yjiW
Putative SOS response protein; Involved in the degradation and recycling of damaged RNA. It is itself a target for degradation by the ATP-dependent protease Lon. Belongs to the SymE family.
      
 0.726
hha
Hemolysin expression modulating protein (involved in environmental regulation of virulence factors); Interacts with H-NS and in this complex might contact DNA, which could provide an additional surface for DNA binding to the H-NS- Hha complex; may not bind DNA in the absence of H-NS. In vitro improves the ability of H-NS to bind DNA under a precise set of conditions.
      
 0.720
clpP
Proteolytic subunit of clpA-clpP ATP-dependent serine protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
     
 0.689
vapB
Putative cytoplasmic protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli neutralizes the effect of cognate toxin VapC.
      
 0.662
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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