STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yhhKPutative acetyltransferase; Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion (By similarity). Binding of CoA or a derivative to PanM leads to interaction with PanD, which promotes the processing and activation of pro-PanD, and subsequent substrate- mediated inhibition of the active form of PanD (By similarity). Lacks acetyltransferase activity. (127 aa)    
Predicted Functional Partners:
panD
Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine; Belongs to the PanD family.
   
 
 0.959
yfcD
Putative NTP pyrophosphohydrolase; Similar to E. coli putative regulator (AAC75359.1); Blastp hit to AAC75359.1 (180 aa), 92% identity in aa 1 - 180.
      
 0.897
ypeA
Putative acetyltransferase; Similar to E. coli orf, hypothetical protein (AAC75487.1); Blastp hit to AAC75487.1 (178 aa), 85% identity in aa 1 - 178; Belongs to the acetyltransferase family. YpeA subfamily.
      
 0.897
yhhY
Putative transferase; Similar to E. coli orf, hypothetical protein (AAC76466.1); Blastp hit to AAC76466.1 (162 aa), 82% identity in aa 1 - 162.
     
 0.897
yhbS
Putative ABC superfamily transport protein; Membrane; similar to E. coli orf, hypothetical protein (AAC76190.1); Blastp hit to AAC76190.1 (167 aa), 96% identity in aa 1 - 167.
   
  
 0.895
ypfI
Putative acetyltransferase; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
      
 0.841
elaA
Putative acyltransferase; Similar to E. coli orf, hypothetical protein (AAC75327.1); Blastp hit to AAC75327.1 (153 aa), 80% identity in aa 1 - 153.
  
  
 0.813
yjgM
Putative acetyltransferase; Hypothetical 18.3 Kda protein in miaE 3'region (ORF 18.3). (SW:YJGM_SALTY); Belongs to the acetyltransferase family.
     
 0.808
phnO
Putative regulator in phn operon; Aminoalkylphosphonate N-acetyltransferase which is able to acetylate a range of aminoalkylphosphonic acids, including (S)-1- aminoethylphosphonate ((S)-1AEP) and 2-aminoethylphosphonate, using acetyl-CoA as acetyl donor. Its physiological role in S.typhimurium is unclear. However, by acetylating (S)-1AEP, PhnO would protect against the deleterious effects of (S)-1AEP, a structural analog of D-alanine that has antibacterial properties.
     
 0.805
yjaB
Putative acetyltransferase; N-epsilon-lysine acetyltransferase that catalyzes acetylation of a large number of proteins; Belongs to the acetyltransferase family.
      
 0.802
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
Server load: medium (80%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.