Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
STM3595Putative phosphatase. (423 aa)    
Predicted Functional Partners:
STM2920
Similar to E. coli transcriptional regulator for cryptic hemolysin (AAC74714.1); Blastp hit to AAC74714.1 (146 aa), 27% identity in aa 1 - 135.
      
 0.859
STM2585A
Gifsy-1 prophage protein; Homolog of pagK.
      
 0.853
STM1547
Putative marR-family transcriptional regulator.
  
   
 0.774
STM1548
Putative S-adenosylmethionine:tRNA-ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
  
  
 0.733
pagD
PhoP regulated; Putative function in virulence. Could be involved in promoting S.typhimurium survival within macrophages.
      
 0.720
STM0082
Putative secreted protein; Similar to E. coli orf, hypothetical protein (AAC76270.1); Blastp hit to AAC76270.1 (104 aa), 36% identity in aa 18 - 103.
      
 0.704
hnr
Response regulator in protein turnover; Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co- degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation.
  
     0.703
STM1633
Similar to E. coli putative periplasmic binding transport protein (AAC74987.1); Blastp hit to AAC74987.1 (266 aa), 25% identity in aa 19 - 232.
      
 0.673
pagC
Reduced macrophage survival protein; Essential for full virulence and survival within macrophages; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. Ail family.
   
  
 0.659
hpaR
4-hydroxyphenylacetate catabolism protein.
      
 0.650
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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