Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
lpfCLong polar fimbrial outer membrane usher protein; Involved in the export and assembly of LpfA fimbrial subunits across the outer membrane; Belongs to the fimbrial export usher family. (842 aa)    
Predicted Functional Partners:
lpfB
Long polar fimbrial chaperone; Required for the biogenesis of long polar fimbria; binds and interact with LpfA; Belongs to the periplasmic pilus chaperone family.
 
 
 0.993
lpfA
Long polar fimbria protein A precursor. (SW:LPFA_SALTY).
 
 
 0.988
lpfE
Long polar fimbrial minor protein; PFE protein precursor (SW:LPFE_SALTY).
  
 
 0.954
msgA
Macrophage survival gene; Affects survival in macrophages.
      
 0.950
sitC
Fur regulated Salmonella iron transporter; SitC (gi|5231096).
      
 0.939
lpfD
Long polar fimbrial operon protein; LPFD protein precursor. (SW:LPFD_SALTY).
  
 
 0.939
pagC
Reduced macrophage survival protein; Essential for full virulence and survival within macrophages; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. Ail family.
   
  
 0.897
prgH
Cell invasion protein; Required for invasion of epithelial cells.
      
 0.896
sifA
Lysosomal glycoprotein (lgp)-containing structures; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required for endosomal tubulation and formation of Salmonella-induced filaments (Sifs), which are filamentous structures containing lysosomal membrane glycoproteins within epithelial cells. Sif formation is concomitant with intracellular bacterial replication.
      
 0.895
invA
Invasion protein; Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
   
  
 0.895
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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