close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lpfCLong polar fimbrial outer membrane usher protein; Involved in the export and assembly of LpfA fimbrial subunits across the outer membrane; Belongs to the fimbrial export usher family. (842 aa)    
Predicted Functional Partners:
lpfB
Long polar fimbrial chaperone; Required for the biogenesis of long polar fimbria; binds and interact with LpfA; Belongs to the periplasmic pilus chaperone family.
 
 
 0.993
lpfA
Long polar fimbria protein A precursor. (SW:LPFA_SALTY).
 
 
 0.987
lpfE
Long polar fimbrial minor protein; PFE protein precursor (SW:LPFE_SALTY).
  
 
 0.961
lpfD
Long polar fimbrial operon protein; LPFD protein precursor. (SW:LPFD_SALTY).
  
 
 0.958
msgA
Macrophage survival gene; Affects survival in macrophages.
      
 0.940
sitC
Fur regulated Salmonella iron transporter; SitC (gi|5231096).
      
 0.940
invA
Invasion protein; Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
   
  
 0.919
pagC
Reduced macrophage survival protein; Essential for full virulence and survival within macrophages; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. Ail family.
      
 0.899
prgH
Cell invasion protein; Required for invasion of epithelial cells.
      
 0.898
sifA
Lysosomal glycoprotein (lgp)-containing structures; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required for endosomal tubulation and formation of Salmonella-induced filaments (Sifs), which are filamentous structures containing lysosomal membrane glycoproteins within epithelial cells. Sif formation is concomitant with intracellular bacterial replication.
      
 0.896
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.