Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
yiaCPutative acetyltransferase; Similar to E. coli orf, hypothetical protein (AAC76574.1); Blastp hit to AAC76574.1 (146 aa), 60% identity in aa 1 - 145. (146 aa)    
Predicted Functional Partners:
rimI
Modification of 30S ribosomal subunit protein S18; Acetylates the N-terminal alanine of ribosomal protein S18.
      
 0.953
phnO
Putative regulator in phn operon; Aminoalkylphosphonate N-acetyltransferase which is able to acetylate a range of aminoalkylphosphonic acids, including (S)-1- aminoethylphosphonate ((S)-1AEP) and 2-aminoethylphosphonate, using acetyl-CoA as acetyl donor. Its physiological role in S.typhimurium is unclear. However, by acetylating (S)-1AEP, PhnO would protect against the deleterious effects of (S)-1AEP, a structural analog of D-alanine that has antibacterial properties.
   
  
 0.952
elaA
Putative acyltransferase; Similar to E. coli orf, hypothetical protein (AAC75327.1); Blastp hit to AAC75327.1 (153 aa), 80% identity in aa 1 - 153.
  
  
 0.919
yfiQ
Putative acetyl-CoA synthetase; Acetylates and inactivates the acetyl-CoA synthase (Acs). Can also acetylate other central metabolic enzymes in response to environmental changes; In the central section; belongs to the acetate CoA ligase beta subunit family.
  
 
 0.900
rimJ
Similar to E. coli acetylation of N-terminal alanine of 30S ribosomal subunit protein S5 (AAC74150.1); Blastp hit to AAC74150.1 (194 aa), 95% identity in aa 1 - 194.
   
  
 0.896
yjgM
Putative acetyltransferase; Hypothetical 18.3 Kda protein in miaE 3'region (ORF 18.3). (SW:YJGM_SALTY); Belongs to the acetyltransferase family.
      
 0.895
ypeA
Putative acetyltransferase; Similar to E. coli orf, hypothetical protein (AAC75487.1); Blastp hit to AAC75487.1 (178 aa), 85% identity in aa 1 - 178; Belongs to the acetyltransferase family. YpeA subfamily.
  
   
 0.873
rimL
Acetyl transferase; Modifies N-terminal serine of 50S ribosomal subunit protein L7/L12; similar to E. coli acetylation of N-terminal serine of 30S ribosomal subunit protein L7; acetyl transferase (AAC74509.1); Blastp hit to AAC74509.1 (179 aa), 67% identity in aa 1 - 178.
   
  
 0.861
cobB
Putative nicotinate-nucleotide dimethylbenzimidazolephosphoribosltransferase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form (By similarity). Activates the enzyme acetyl-CoA synthetase by deacetylating 'Lys-609' in the inactive, acetylated form of the enzyme. May also modulate the activity of other propionyl-adenosine monophosphate (AMP)-forming enzymes. Overexpression compensates for a cobT deletion, suggesting it may have [...]
     
 0.860
yiiD
Similar to E. coli putative acetyltransferase (AAD13450.1); Blastp hit to AAD13450.1 (329 aa), 93% identity in aa 1 - 329.
      
 0.859
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.