Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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yiaHPutative inner membrane protein; Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units. (331 aa)    
Predicted Functional Partners:
mdoC
Membrane protein; Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane.
 
  
 0.811
aroM
Similar to E. coli protein of aro operon, regulated by aroR (AAC73493.1); Blastp hit to AAC73493.1 (225 aa), 77% identity in aa 1 - 225.
  
    0.747
oafA
Acetylation of the O-antigen (LPS); O-antigen five:.
     
 0.739
ypfG
Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75519.1); Blastp hit to AAC75519.1 (347 aa), 77% identity in aa 1 - 347.
  
    0.727
oat
Putative acetylornithine aminotransferase; Catalyzes the aminotransferase reaction from putrescine to 2- oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4- aminobutanal. Also functions as a cadaverine transaminase in a a L- lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
      
 0.726
csiE
Stationary phase inducible protein; Similar to E. coli orf, hypothetical protein (AAC75588.1); Blastp hit to AAC75588.1 (433 aa), 71% identity in aa 8 - 432.
  
     0.721
iap
Similar to E. coli alkaline phosphatase isozyme conversion, aminopeptidase (AAC75795.1); Blastp hit to AAC75795.1 (345 aa), 85% identity in aa 1 - 344.
  
     0.721
ybbM
Similar to E. coli putative metal resistance protein (AAC73593.1); Blastp hit to AAC73593.1 (268 aa), 88% identity in aa 10 - 267.
      
 0.700
rsd
Regulator of sigma D; Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.
  
     0.680
yojN
Putative sensor/kinase in regulatory system; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB.
  
     0.676
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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