Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
rhuMPutative cytoplasmic protein; Pathogenicity island encoded protein: SPI3; RhuM (gi|4324608). (345 aa)    
Predicted Functional Partners:
sugR
ATP binding protein; Putative cytoplasmic protein; Pathogenicity island encoded protein: SPI3; putative ATP binding protein SugR (gi|4324607).
  
  
 0.972
hsdM
DNA methylase M, host modification; Methylation of specific adenine residues; required for both restriction and modification activities (By similarity). The StySJI enzyme recognizes 5'-GAGN(6)GTRC-3'; Belongs to the N(4)/N(6)-methyltransferase family.
 
    0.848
STM3754
Pathogenicity island encoded protein: SPI3; putative ATP binding protein SugR (gi|4324607).
  
  
 0.820
STM3752
Putative cytoplasmic protein; Pathogenicity island encoded protein: SPI3.
   
  
 0.814
rmbA
Putative cytoplasmic protein; Pathogenicity island encoded protein: SPI3; RmbA (gi|4324609).
   
  
 0.753
hsdS
Specificity determinant for hsdM and hsdR; The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance M [...]
 
    0.749
pipC
Pathogenicity island encoded protein: SPI5; Molecular chaperone required for SopB/SigD stabilization and secretion; Belongs to the IpgE/SigE chaperone family.
      
 0.723
avrA
Putative inner membrane protein.
      
 0.723
iacP
Putative acyl carrier protein; Acyl carrier protein.
      
 0.717
orfX
Pathogenicity island encoded protein: SPI5.
      
 0.680
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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