STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uhpBSensory histidine kinase in two-component regulatory sytem with UhpA; Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpB functions as a membrane-associated protein kinase that autophosphorylates in response to interaction with UhpC, and subsequently transfers its phosphate group to the response regulator UhpA. Can also dephosphorylate UhpA. (500 aa)    
Predicted Functional Partners:
uhpC
Regulator of uhpT expression; Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC senses external glucose-6-phosphate and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
 
 0.999
uhpA
Response regulator (repressor) in two-component regulatory system wtih UhpB; Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. Activates the transcription of the uhpT gene. Acts by binding specifically to the uhpT promoter region.
 0.999
uhpT
MFS family hexose phosphate transport protein; Mediates the exchange of external hexose 6-phosphate and internal inorganic phosphate.
  
 0.985
STM2198
Putative regulatory protein; Similar to E. coli regulator of uhpT (AAC76690.1); Blastp hit to AAC76690.1 (440 aa), 39% identity in aa 5 - 428.
 
 
  0.917
narP
Response regulator in two-component regulatory system with NarQ (or NarX); Similar to E. coli nitrate/nitrite response regulator (sensor NarQ) (AAC75253.1); Blastp hit to AAC75253.1 (215 aa), 88% identity in aa 1 - 215.
 
 0.826
narL
Response regulator in two-component regulatory system with NarX (or NarQ); Regulates anaerobic respiration and fermentation (LuxR/UhpA family); similar to E. coli pleiotrophic regulation of anaerobic respiration: response regulator for nar, frd, dms and tor genes (AAC74305.1); Blastp hit to AAC74305.1 (216 aa), 96% identity in aa 1 - 216.
 
 
 0.755
yhjB
LuxR/UhpA family; similar to E. coli putative regulator (AAC76545.1); Blastp hit to AAC76545.1 (200 aa), 72% identity in aa 1 - 200.
 
   0.748
fimZ
Fimbrial protein Z; Putative transcriptional regulator (LuxR/UhpA family); fimbriae Z protein. (SW:FIMZ_SALTY).
 
   0.744
ssrB
Secretion system regulator: transcriptonal activator; Homologous with degU/uvrY/bvgA; SsrB (gi|2765824).
 
 
 0.729
rcsB
LuxR/UhpA family response regulator in two-component regulatory system with RcsC; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner.
 
   0.720
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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