Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-expression
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[Homology]
Score
emrDMFS family multidrug tranport protein; Similar to E. coli 2-module integral membrane pump; multidrug resistance (AAC76696.1); Blastp hit to AAC76696.1 (396 aa), 92% identity in aa 3 - 396. (394 aa)    
Predicted Functional Partners:
emrB
Putative MFS superfamily multidrug transport protein; Similar to E. coli multidrug resistance; probably membrane translocase (AAC75733.1); Blastp hit to AAC75733.1 (512 aa), 95% identity in aa 1 - 512; Belongs to the major facilitator superfamily.
  
  
 0.914
emrA
Similar to E. coli multidrug resistance secretion protein (AAC75732.1); Blastp hit to AAC75732.1 (390 aa), 89% identity in aa 1 - 390.
   
 
 0.875
acrD
RND family aminoglycoside/multidrug efflux pump; Similar to E. coli sensitivity to acriflavine, integral membrane protein, possible efflux pump (AAC75523.1); Blastp hit to AAC75523.1 (1037 aa), 94% identity in aa 1 - 1037.
      
 0.852
yceE
Similar to E. coli putative transport protein (AAC74137.1); Blastp hit to AAC74137.1 (408 aa), 27% identity in aa 1 - 404.
  
   
 0.821
acrA
Similar to E. coli acridine efflux pump (AAC73565.1); Blastp hit to AAC73565.1 (397 aa), 91% identity in aa 1 - 397; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
      
 0.810
tolC
Outer membrane channel; Specific tolerance to colicin E1; segregation of daughter chromosomes; role in organic solvent tolerance; similar to E. coli outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (AAC76071.1); Blastp hit to AAC76071.1 (495 aa), 89% identity in aa 1 - 495.
   
 
 0.794
ydhE
Putative MATE family transport protein; Multidrug efflux pump that functions probably as a Na(+)/drug antiporter; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.
     
 0.730
acrF
RND family multidrug transport protein; Similar to E. coli integral transmembrane protein; acridine resistance (AAC76298.1); Blastp hit to AAC76298.1 (1034 aa), 22% identity in aa 1 - 506; acriflavin resistance protein F.
   
  
 0.726
yegO
Putative resistance protein; Efflux transporter; outer membrane; similar to E. coli orf, hypothetical protein (AAC75137.1); Blastp hit to AAC75137.1 (1025 aa), 91% identity in aa 1 - 1025; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily.
      
 0.717
mdlB
Putative ABC superfamily (atp&membrane) transporter; Similar to E. coli putative ATP-binding component of a transport system (AAC73552.1); Blastp hit to AAC73552.1 (593 aa), 88% identity in aa 1 - 593.
   
  
 0.703
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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