Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dgoAGalactonate dehydratase; Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy- D-galactonate. (382 aa)    
Predicted Functional Partners:
dgoK
Similar to E. coli 2-oxo-3-deoxygalactonate kinase (AAC76716.1); Blastp hit to AAC76716.1 (292 aa), 81% identity in aa 1 - 292.
 
 0.999
dgoR
Galactonate operon transcriptional repressor; GntR family; similar to E. coli regulator protein for dgo operon (AAC76718.1); Blastp hit to AAC76718.1 (128 aa), 94% identity in aa 1 - 112.
  
 0.943
dgoT
MFS family D-galactonate transport protein; Similar to E. coli D-galactonate transport (AAC76714.1); Blastp hit to AAC76714.1 (445 aa), 90% identity in aa 1 - 445.
  
  
 0.931
STM3698
Similar to E. coli putative transport protein (AAC75831.1); Blastp hit to AAC75831.1 (450 aa), 49% identity in aa 9 - 444.
  
  
 0.899
STM3134
Putative permease; Similar to E. coli transport of hexuronates (AAC76128.1); Blastp hit to AAC76128.1 (472 aa), 47% identity in aa 43 - 454.
  
  
 0.854
yibD
Similar to E. coli putative regulator (AAC76639.1); Blastp hit to AAC76639.1 (344 aa), 80% identity in aa 1 - 343.
      
 0.672
STM3697
Putative mandelate racemase; Catalyzes the efficient dehydration of both L-talarate and galactarate to 5-keto-4-deoxy-D-glucarate. Also catalyzes the epimerization of L-talarate to galactarate; epimerization occurs in competition with dehydration. Is required for the utilization of L- talarate as a carbon source. Also functions in galactarate utilization. Is not active on other acid sugars; Belongs to the mandelate racemase/muconate lactonizing enzyme family.
  
  
0.581
yidR
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC76712.1); Blastp hit to AAC76712.1 (416 aa), 79% identity in aa 13 - 416.
 
    0.535
STM3169
Similar to E. coli putative solute-binding transport protein (AAC76603.1); Blastp hit to AAC76603.1 (328 aa), 28% identity in aa 7 - 320.
   
  
 0.527
yfaW
Putative galactonate dehydratase; Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy- L-rhamnonate (KDR). Can also dehydrate L-lyxonate and L-mannonate, although less efficiently, but not 2-keto-4-hydroxyheptane-1,7-dioate. Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily.
  
   
0.491
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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