Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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rbsRTranscriptional repressor for rbs operon (GalR/LacI family); Similar to E. coli regulator for rbs operon (AAC76776.1); Blastp hit to AAC76776.1 (330 aa), 89% identity in aa 1 - 329. (332 aa)    
Predicted Functional Partners:
rbsK
Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
  
 0.957
rbsK-2
Putative transcriptional regulator of sugar metabolism; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
 
  
 0.863
rbsK-3
Putative sugar kinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
 
  
 0.856
rbsC
D-ribose high-affinity transport protein (1st module, ATP-binding subunit); ABC superfamily (membrane); similar to E. coli D-ribose high-affinity transport system (AAC76773.1); Blastp hit to AAC76773.1 (321 aa), 96% identity in aa 1 - 321; Belongs to the binding-protein-dependent transport system permease family.
 
  
 0.806
orf408
Putative regulatory protein, deoR family; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
 
  
 0.804
rbsD
D-ribose high-affinity transport system; Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
 
  
 0.798
rbsA
D-ribose high-affinity transport protein; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
  
  
 0.706
rbsB
D-ribose transport protein; Part of the ABC transporter complex RbsABC involved in ribose import. Binds ribose.
 
  
0.705
gltB
Similar to E. coli glutamate synthase, large subunit (AAC76244.1); Blastp hit to AAC76244.1 (1517 aa), 95% identity in aa 32 - 1517.
    
 
 0.667
dgoR
Galactonate operon transcriptional repressor; GntR family; similar to E. coli regulator protein for dgo operon (AAC76718.1); Blastp hit to AAC76718.1 (128 aa), 94% identity in aa 1 - 112.
    
 
 0.590
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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