| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ilvA | ilvB | STM3905 | STM3796 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/threon [...] | Valine sensitive; similar to E. coli acetolactate synthase I,valine-sensitive, large subunit (AAC76694.1); Blastp hit to AAC76694.1 (562 aa), 91% identity in aa 1 - 562. | 0.976 |
| ilvA | ilvC | STM3905 | STM3909 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/threon [...] | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.940 |
| ilvA | ilvD | STM3905 | STM3904 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/threon [...] | Dihydroxy-acid dehydratase. (SW:ILVD_SALTY); Belongs to the IlvD/Edd family. | 0.998 |
| ilvA | ilvE | STM3905 | STM3903 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/threon [...] | Branched-chain amino-acid aminotransferase; Acts on leucine, isoleucine and valine. | 0.998 |
| ilvA | ilvG | STM3905 | STM3901 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/threon [...] | Fragment 1; cryptic; similar to E. coli acetolactate synthase II, large subunit, cryptic, interrupted (AAC77488.1); Blastp hit to AAC77488.1 (327 aa), 93% identity in aa 1 - 325. | 0.994 |
| ilvA | ilvH | STM3905 | STM0117 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/threon [...] | Acetolactate synthase isozyme III small subunit. (SW:ILVH_SALTY). | 0.985 |
| ilvA | leuA | STM3905 | STM0113 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/threon [...] | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.889 |
| ilvA | leuB | STM3905 | STM0112 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/threon [...] | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.982 |
| ilvA | leuC | STM3905 | STM0111 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/threon [...] | 3-isopropylmalate isomerase (dehydratase), subunit with LeuD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.562 |
| ilvA | leuD | STM3905 | STM0110 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/threon [...] | 3-isopropylmalate isomerase (dehydratase), subunit with LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.690 |
| ilvB | ilvA | STM3796 | STM3905 | Valine sensitive; similar to E. coli acetolactate synthase I,valine-sensitive, large subunit (AAC76694.1); Blastp hit to AAC76694.1 (562 aa), 91% identity in aa 1 - 562. | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/threon [...] | 0.976 |
| ilvB | ilvC | STM3796 | STM3909 | Valine sensitive; similar to E. coli acetolactate synthase I,valine-sensitive, large subunit (AAC76694.1); Blastp hit to AAC76694.1 (562 aa), 91% identity in aa 1 - 562. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.994 |
| ilvB | ilvD | STM3796 | STM3904 | Valine sensitive; similar to E. coli acetolactate synthase I,valine-sensitive, large subunit (AAC76694.1); Blastp hit to AAC76694.1 (562 aa), 91% identity in aa 1 - 562. | Dihydroxy-acid dehydratase. (SW:ILVD_SALTY); Belongs to the IlvD/Edd family. | 0.957 |
| ilvB | ilvE | STM3796 | STM3903 | Valine sensitive; similar to E. coli acetolactate synthase I,valine-sensitive, large subunit (AAC76694.1); Blastp hit to AAC76694.1 (562 aa), 91% identity in aa 1 - 562. | Branched-chain amino-acid aminotransferase; Acts on leucine, isoleucine and valine. | 0.826 |
| ilvB | ilvG | STM3796 | STM3901 | Valine sensitive; similar to E. coli acetolactate synthase I,valine-sensitive, large subunit (AAC76694.1); Blastp hit to AAC76694.1 (562 aa), 91% identity in aa 1 - 562. | Fragment 1; cryptic; similar to E. coli acetolactate synthase II, large subunit, cryptic, interrupted (AAC77488.1); Blastp hit to AAC77488.1 (327 aa), 93% identity in aa 1 - 325. | 0.935 |
| ilvB | ilvH | STM3796 | STM0117 | Valine sensitive; similar to E. coli acetolactate synthase I,valine-sensitive, large subunit (AAC76694.1); Blastp hit to AAC76694.1 (562 aa), 91% identity in aa 1 - 562. | Acetolactate synthase isozyme III small subunit. (SW:ILVH_SALTY). | 0.999 |
| ilvB | leuA | STM3796 | STM0113 | Valine sensitive; similar to E. coli acetolactate synthase I,valine-sensitive, large subunit (AAC76694.1); Blastp hit to AAC76694.1 (562 aa), 91% identity in aa 1 - 562. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.988 |
| ilvB | leuB | STM3796 | STM0112 | Valine sensitive; similar to E. coli acetolactate synthase I,valine-sensitive, large subunit (AAC76694.1); Blastp hit to AAC76694.1 (562 aa), 91% identity in aa 1 - 562. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.982 |
| ilvB | leuC | STM3796 | STM0111 | Valine sensitive; similar to E. coli acetolactate synthase I,valine-sensitive, large subunit (AAC76694.1); Blastp hit to AAC76694.1 (562 aa), 91% identity in aa 1 - 562. | 3-isopropylmalate isomerase (dehydratase), subunit with LeuD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.859 |
| ilvB | leuD | STM3796 | STM0110 | Valine sensitive; similar to E. coli acetolactate synthase I,valine-sensitive, large subunit (AAC76694.1); Blastp hit to AAC76694.1 (562 aa), 91% identity in aa 1 - 562. | 3-isopropylmalate isomerase (dehydratase), subunit with LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.862 |
