| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| alr | aspC | STM4247 | STM0998 | Biosynthetic alanine racemase 1; Catalyzes the interconversion of L-alanine and D-alanine. Provides the D-alanine required for cell wall biosynthesis. | Similar to E. coli aspartate aminotransferase (AAC74014.1); Blastp hit to AAC74014.1 (396 aa), 95% identity in aa 1 - 396; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 0.754 |
| alr | ilvA | STM4247 | STM3905 | Biosynthetic alanine racemase 1; Catalyzes the interconversion of L-alanine and D-alanine. Provides the D-alanine required for cell wall biosynthesis. | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/threon [...] | 0.701 |
| alr | ilvE | STM4247 | STM3903 | Biosynthetic alanine racemase 1; Catalyzes the interconversion of L-alanine and D-alanine. Provides the D-alanine required for cell wall biosynthesis. | Branched-chain amino-acid aminotransferase; Acts on leucine, isoleucine and valine. | 0.869 |
| alr | tdcB | STM4247 | STM3244 | Biosynthetic alanine racemase 1; Catalyzes the interconversion of L-alanine and D-alanine. Provides the D-alanine required for cell wall biosynthesis. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. TdcB also dehydrates serine to yield pyruv [...] | 0.487 |
| alr | yigF | STM4247 | STM3953 | Biosynthetic alanine racemase 1; Catalyzes the interconversion of L-alanine and D-alanine. Provides the D-alanine required for cell wall biosynthesis. | Putative inner membrane protein; Hypothetical 14.6 Kda protein in corA-rarD intergenic region. (SW:YIGF_SALTY). | 0.650 |
| alr | yjgF | STM4247 | STM4458 | Biosynthetic alanine racemase 1; Catalyzes the interconversion of L-alanine and D-alanine. Provides the D-alanine required for cell wall biosynthesis. | Putative translation initiation inhibitor; Accelerates the release of ammonia from reactive enamine/imine intermediates of the PLP-dependent threonine dehydratase (IlvA) in the low water environment of the cell. It catalyzes the deamination of enamine/imine intermediates to yield 2-ketobutyrate and ammonia. It is required for the detoxification of reactive intermediates of IlvA due to their highly nucleophilic abilities and to avoid they are captured by anthranilate phosphoribosyltransferase (TrpD) to generate PRA, an intermediate in the alternative pyrimidine biosynthetic (APB) pathwa [...] | 0.509 |
| aspC | alr | STM0998 | STM4247 | Similar to E. coli aspartate aminotransferase (AAC74014.1); Blastp hit to AAC74014.1 (396 aa), 95% identity in aa 1 - 396; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Biosynthetic alanine racemase 1; Catalyzes the interconversion of L-alanine and D-alanine. Provides the D-alanine required for cell wall biosynthesis. | 0.754 |
| aspC | ilvA | STM0998 | STM3905 | Similar to E. coli aspartate aminotransferase (AAC74014.1); Blastp hit to AAC74014.1 (396 aa), 95% identity in aa 1 - 396; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/threon [...] | 0.496 |
| aspC | ilvE | STM0998 | STM3903 | Similar to E. coli aspartate aminotransferase (AAC74014.1); Blastp hit to AAC74014.1 (396 aa), 95% identity in aa 1 - 396; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Branched-chain amino-acid aminotransferase; Acts on leucine, isoleucine and valine. | 0.873 |
| aspC | yigF | STM0998 | STM3953 | Similar to E. coli aspartate aminotransferase (AAC74014.1); Blastp hit to AAC74014.1 (396 aa), 95% identity in aa 1 - 396; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Putative inner membrane protein; Hypothetical 14.6 Kda protein in corA-rarD intergenic region. (SW:YIGF_SALTY). | 0.512 |
| aspC | yjgF | STM0998 | STM4458 | Similar to E. coli aspartate aminotransferase (AAC74014.1); Blastp hit to AAC74014.1 (396 aa), 95% identity in aa 1 - 396; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Putative translation initiation inhibitor; Accelerates the release of ammonia from reactive enamine/imine intermediates of the PLP-dependent threonine dehydratase (IlvA) in the low water environment of the cell. It catalyzes the deamination of enamine/imine intermediates to yield 2-ketobutyrate and ammonia. It is required for the detoxification of reactive intermediates of IlvA due to their highly nucleophilic abilities and to avoid they are captured by anthranilate phosphoribosyltransferase (TrpD) to generate PRA, an intermediate in the alternative pyrimidine biosynthetic (APB) pathwa [...] | 0.594 |
| ilvA | alr | STM3905 | STM4247 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/threon [...] | Biosynthetic alanine racemase 1; Catalyzes the interconversion of L-alanine and D-alanine. Provides the D-alanine required for cell wall biosynthesis. | 0.701 |
| ilvA | aspC | STM3905 | STM0998 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/threon [...] | Similar to E. coli aspartate aminotransferase (AAC74014.1); Blastp hit to AAC74014.1 (396 aa), 95% identity in aa 1 - 396; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 0.496 |
| ilvA | ilvE | STM3905 | STM3903 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/threon [...] | Branched-chain amino-acid aminotransferase; Acts on leucine, isoleucine and valine. | 0.998 |
| ilvA | tdcB | STM3905 | STM3244 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/threon [...] | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. TdcB also dehydrates serine to yield pyruv [...] | 0.924 |
| ilvA | yigF | STM3905 | STM3953 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/threon [...] | Putative inner membrane protein; Hypothetical 14.6 Kda protein in corA-rarD intergenic region. (SW:YIGF_SALTY). | 0.549 |
| ilvA | yjgF | STM3905 | STM4458 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/threon [...] | Putative translation initiation inhibitor; Accelerates the release of ammonia from reactive enamine/imine intermediates of the PLP-dependent threonine dehydratase (IlvA) in the low water environment of the cell. It catalyzes the deamination of enamine/imine intermediates to yield 2-ketobutyrate and ammonia. It is required for the detoxification of reactive intermediates of IlvA due to their highly nucleophilic abilities and to avoid they are captured by anthranilate phosphoribosyltransferase (TrpD) to generate PRA, an intermediate in the alternative pyrimidine biosynthetic (APB) pathwa [...] | 0.986 |
| ilvE | alr | STM3903 | STM4247 | Branched-chain amino-acid aminotransferase; Acts on leucine, isoleucine and valine. | Biosynthetic alanine racemase 1; Catalyzes the interconversion of L-alanine and D-alanine. Provides the D-alanine required for cell wall biosynthesis. | 0.869 |
| ilvE | aspC | STM3903 | STM0998 | Branched-chain amino-acid aminotransferase; Acts on leucine, isoleucine and valine. | Similar to E. coli aspartate aminotransferase (AAC74014.1); Blastp hit to AAC74014.1 (396 aa), 95% identity in aa 1 - 396; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 0.873 |
| ilvE | ilvA | STM3903 | STM3905 | Branched-chain amino-acid aminotransferase; Acts on leucine, isoleucine and valine. | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/threon [...] | 0.998 |
