Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
yihEPutative homoserine kinase type II; A protein kinase that (auto)phosphorylates on Ser and Thr residues, probably involved in the extracytoplasmic stress response. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species (By similarity). (328 aa)    
Predicted Functional Partners:
dsbA
Periplasmic protein disulfide isomerase I; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. It is required for pilus biogenesis (By similarity). Belongs to the thioredoxin family. DsbA subfamily.
 
  
 0.983
yihD
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC76856.1); Blastp hit to AAC76856.1 (89 aa), 94% identity in aa 1 - 89.
 
    0.955
yaeP
Putative cytoplasmic protein; Belongs to the UPF0253 family.
   
  
 0.851
yeaG
Putative Ser protein kinase; Similar to E. coli orf, hypothetical protein (AAC74853.1); Blastp hit to AAC74853.1 (644 aa), 98% identity in aa 1 - 644.
      
 0.700
ydgF
Putative membrane transporter of cations and cationic drugs; Catalyzes the excretion of spermidine.
   
  
 0.557
spy
Similar to E. coli periplasmic protein related to spheroblast formation (AAC74813.1); Blastp hit to AAC74813.1 (161 aa), 89% identity in aa 1 - 161.
      
 0.516
modE
Transcriptional repressor of modABCD operon (molybdate uptake); Similar to E. coli molybdate uptake regulatory protein (AAC73848.1); Blastp hit to AAC73848.1 (262 aa), 89% identity in aa 1 - 262.
     
 0.515
yqgB
Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC75976.1); Blastp hit to AAC75976.1 (48 aa), 73% identity in aa 6 - 46.
      
 0.514
yccA
Similar to E. coli putative carrier/transport protein (AAC74056.1); Blastp hit to AAC74056.1 (219 aa), 94% identity in aa 1 - 219; Belongs to the BI1 family.
  
  
 0.494
asd
Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
 
  
 0.489
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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