typA protein (Salmonella enterica Typhimurium)

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typA

GTP-binding elongation factor family protein; A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA (By similarity). A ribosome-stimulated GTPase, GTPase activity increases 4 fold in the presence of 70S ribosomes. Bind to 70S ribosomes in the presence of GTP or its non- hydrolyzable analog [...] (607 aa)

Predicted Functional Partners:

engA

0.782

glnA

0.780

guaA

0.777

rbn

0.723

tig

0.710

ychF

0.697

trmD

0.695

tsf

0.687

rpoB

0.672

rpsI

0.670

Your Current Organism:

Salmonella enterica Typhimurium

NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
engA	guaA	STM2519	STM2510	Putative GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis.	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	0.617
engA	trmD	STM2519	STM2674	Putative GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis.	tRNA (guanine-7-)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family.	0.457
engA	tsf	STM2519	STM0217	Putative GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis.	Protein chain elongation factor EF-Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.	0.652
engA	typA	STM2519	STM4009	Putative GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis.	GTP-binding elongation factor family protein; A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA (By similarity). A ribosome-stimulated GTPase, GTPase activity increases 4 fold in the presence of 70S ribosomes. Bind to 70S ribosomes in the presence of GTP or its non- hydrolyzable analog [...]	0.782
engA	ychF	STM2519	STM1784	Putative GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis.	Putative GTP-binding protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.	0.551
glnA	guaA	STM4007	STM2510	Glutamine synthetase; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	0.775
glnA	rpoB	STM4007	STM4153	Glutamine synthetase; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.	RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.620
glnA	typA	STM4007	STM4009	Glutamine synthetase; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.	GTP-binding elongation factor family protein; A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA (By similarity). A ribosome-stimulated GTPase, GTPase activity increases 4 fold in the presence of 70S ribosomes. Bind to 70S ribosomes in the presence of GTP or its non- hydrolyzable analog [...]	0.780
guaA	engA	STM2510	STM2519	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	Putative GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis.	0.617
guaA	glnA	STM2510	STM4007	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	Glutamine synthetase; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.	0.775
guaA	rpoB	STM2510	STM4153	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.929
guaA	rpsI	STM2510	STM3344	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	Similar to E. coli 30S ribosomal subunit protein S9 (AAC76262.1); Blastp hit to AAC76262.1 (130 aa), 99% identity in aa 1 - 130.	0.654
guaA	tig	STM2510	STM0447	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	Peptidyl-prolyl cis/trans isomerase; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.	0.594
guaA	trmD	STM2510	STM2674	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	tRNA (guanine-7-)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family.	0.744
guaA	tsf	STM2510	STM0217	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	Protein chain elongation factor EF-Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.	0.578
guaA	typA	STM2510	STM4009	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	GTP-binding elongation factor family protein; A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA (By similarity). A ribosome-stimulated GTPase, GTPase activity increases 4 fold in the presence of 70S ribosomes. Bind to 70S ribosomes in the presence of GTP or its non- hydrolyzable analog [...]	0.777
guaA	ychF	STM2510	STM1784	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	Putative GTP-binding protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.	0.718
rbn	typA	STM4027	STM4009	Similar to E. coli tRNA processing exoribonuclease BN (AAD13448.1); Blastp hit to AAD13448.1 (290 aa), 93% identity in aa 1 - 290.	GTP-binding elongation factor family protein; A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA (By similarity). A ribosome-stimulated GTPase, GTPase activity increases 4 fold in the presence of 70S ribosomes. Bind to 70S ribosomes in the presence of GTP or its non- hydrolyzable analog [...]	0.723
rpoB	glnA	STM4153	STM4007	RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Glutamine synthetase; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.	0.620
rpoB	guaA	STM4153	STM2510	RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	0.929

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