STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
nrfEFormate-dependent nitrite reductase; Possible subunit of a heme lyase. (740 aa)    
Predicted Functional Partners:
nrfG
Involved in attachment of haem c to cytochrome c552; similar to E. coli part of formate-dependent nitrite reductase complex (AAD13459.1); Blastp hit to AAD13459.1 (198 aa), 71% identity in aa 6 - 196.
 
 0.990
nrfA
Nitrite reductase periplasmic cytochrome c(552); Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family.
 
  
 0.976
nrfD
Similar to E. coli formate-dependent nitrate reductase complex; transmembrane protein (AAC77043.1); Blastp hit to AAC77043.1 (318 aa), 85% identity in aa 1 - 318.
 
  
 0.959
ccmG
Heme lyase/disulfide oxidoreductase; Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity); Belongs to the thioredoxin family. DsbE subfamily.
 
  
 0.926
ccmG-2
Heme lyase disulfide oxidoreductase; Cytochrome c-type biogenesis; similar to E. coli disulfide oxidoreductase (in biogenesis of cytochrome c? (AAC75255.1); Blastp hit to AAC75255.1 (185 aa), 87% identity in aa 1 - 185.
 
  
 0.926
ccmE
Periplasmic heme-dependent peroxidase; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family.
 
 
 0.922
ccmE-2
Periplasmic heme-dependent peroxidase; Cytochrome c-type biogenesis protein; similar to E. coli cytochrome c biogenesis, possible subunit of a heme lyase (AAC75257.1); Blastp hit to AAC75257.1 (159 aa), 82% identity in aa 1 - 159.
 
 
 0.922
nrfB
Formate-dependent nitrite reductase; A penta-haeme cytochrome c; similar to E. coli formate-dependent nitrite reductase; a penta-haeme cytochrome c (AAC77041.1); Blastp hit to AAC77041.1 (190 aa), 88% identity in aa 1 - 190.
 
  
 0.916
ccmC
Heme exporter protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family.
 
  
 0.887
ccmC-2
Cytochrome c-type biogenesis protein; similar to E. coli heme exporter protein C (AAC75259.1); Blastp hit to AAC75259.1 (245 aa), 86% identity in aa 1 - 245.
 
  
 0.887
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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