STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
phnOPutative regulator in phn operon; Aminoalkylphosphonate N-acetyltransferase which is able to acetylate a range of aminoalkylphosphonic acids, including (S)-1- aminoethylphosphonate ((S)-1AEP) and 2-aminoethylphosphonate, using acetyl-CoA as acetyl donor. Its physiological role in S.typhimurium is unclear. However, by acetylating (S)-1AEP, PhnO would protect against the deleterious effects of (S)-1AEP, a structural analog of D-alanine that has antibacterial properties. (154 aa)    
Predicted Functional Partners:
phnW
2-aminoethylphosphonate transport; Involved in phosphonate degradation.
     
 0.985
rimI
Modification of 30S ribosomal subunit protein S18; Acetylates the N-terminal alanine of ribosomal protein S18.
      
 0.953
yiaC
Putative acetyltransferase; Similar to E. coli orf, hypothetical protein (AAC76574.1); Blastp hit to AAC76574.1 (146 aa), 60% identity in aa 1 - 145.
   
  
 0.952
yjaB
Putative acetyltransferase; N-epsilon-lysine acetyltransferase that catalyzes acetylation of a large number of proteins; Belongs to the acetyltransferase family.
      
 0.951
yhhY
Putative transferase; Similar to E. coli orf, hypothetical protein (AAC76466.1); Blastp hit to AAC76466.1 (162 aa), 82% identity in aa 1 - 162.
  
  
 0.870
rimL
Acetyl transferase; Modifies N-terminal serine of 50S ribosomal subunit protein L7/L12; similar to E. coli acetylation of N-terminal serine of 30S ribosomal subunit protein L7; acetyl transferase (AAC74509.1); Blastp hit to AAC74509.1 (179 aa), 67% identity in aa 1 - 178.
   
  
 0.864
elaA
Putative acyltransferase; Similar to E. coli orf, hypothetical protein (AAC75327.1); Blastp hit to AAC75327.1 (153 aa), 80% identity in aa 1 - 153.
     
 0.861
phnX
2-aminoethylphosphonate transport; Involved in phosphonate degradation.
   
  
 0.860
ypfI
Putative acetyltransferase; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
      
 0.859
rimJ
Similar to E. coli acetylation of N-terminal alanine of 30S ribosomal subunit protein S5 (AAC74150.1); Blastp hit to AAC74150.1 (194 aa), 95% identity in aa 1 - 194.
   
  
 0.857
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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