STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
phnBPutative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC77068.1); Blastp hit to AAC77068.1 (147 aa), 83% identity in aa 1 - 145. (147 aa)    
Predicted Functional Partners:
phnA
Putative alkylphosphonate uptake protein in phosphonate metabolism; Similar to E. coli orf, hypothetical protein (AAC77069.1); Blastp hit to AAC77069.1 (111 aa), 96% identity in aa 1 - 111.
     
 0.970
phnR
2-aminoethylphosphonate transport, repressor; Probable repressor protein of GntR family phnR (gi|11354257).
   
  
 0.899
phnW
2-aminoethylphosphonate transport; Involved in phosphonate degradation.
      
 0.896
STM3254
Putative fructose-1-phosphate kinase; Similar to E. coli 6-phosphofructokinase II; suppressor of pfkA (AAC74793.1); Blastp hit to AAC74793.1 (309 aa), 27% identity in aa 4 - 291; Belongs to the carbohydrate kinase PfkB family.
      
 0.831
nadR
Trifunctional protein; This enzyme has three activities: DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase within the cell, the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity catalyzes the transfer of the A [...]
   
    0.823
phnX
2-aminoethylphosphonate transport; Involved in phosphonate degradation.
      
 0.809
phnO
Putative regulator in phn operon; Aminoalkylphosphonate N-acetyltransferase which is able to acetylate a range of aminoalkylphosphonic acids, including (S)-1- aminoethylphosphonate ((S)-1AEP) and 2-aminoethylphosphonate, using acetyl-CoA as acetyl donor. Its physiological role in S.typhimurium is unclear. However, by acetylating (S)-1AEP, PhnO would protect against the deleterious effects of (S)-1AEP, a structural analog of D-alanine that has antibacterial properties.
 
  
 0.773
fruK
Similar to E. coli fructose-1-phosphate kinase (AAC75229.1); Blastp hit to AAC75229.1 (312 aa), 98% identity in aa 1 - 312; Belongs to the carbohydrate kinase PfkB family.
      
 0.579
STM1643
Putative inner membrane protein.
  
    0.547
STM0409
Hypothetical protein.
 
  
 0.520
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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