Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
adiArginine decarboxylase; Catabolic; inducible by acid; similar to E. coli biodegradative arginine decarboxylase (AAC77078.1); Blastp hit to AAC77078.1 (756 aa), 92% identity in aa 1 - 756. (756 aa)    
Predicted Functional Partners:
yjdE
Putative APC family putrescine/ornithine transport protein; Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular protons. Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
 
  
 0.927
speA
Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine.
     
 0.910
astA
Arginine succinyltransferase; Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine.
   
 
  0.908
speB
Agmatinase; Catalyzes the formation of putrescine from agmatine. Belongs to the arginase family. Agmatinase subfamily.
    
 0.905
arcA-2
Putative arginine deiminase.
     
 0.810
argH
Similar to E. coli argininosuccinate lyase (AAC76942.1); Blastp hit to AAC76942.1 (457 aa), 94% identity in aa 1 - 456.
     
 0.809
potE
APC family, putrescine/ornithine antiporter; Catalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine antiporter activity. Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
 
  
 0.669
yieN
Putative regulator protein; Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone; Belongs to the RavA family.
   
   0.648
adiY
Transcriptional activator of adiA; AraC/XylS family; similar to E. coli putative ARAC-type regulatory protein (AAC77077.1); Blastp hit to AAC77077.1 (253 aa), 79% identity in aa 1 - 253.
  
    0.602
cadB
APC family lysine/cadaverine transport protein; Similar to E. coli transport of lysine/cadaverine (AAC77093.1); Blastp hit to AAC77093.1 (444 aa), 90% identity in aa 1 - 440.
 
   
 0.490
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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