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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
melRAraC/XylS family; similar to E. coli regulator of melibiose operon (AAC77079.1); Blastp hit to AAC77079.1 (302 aa), 88% identity in aa 4 - 302. (310 aa)    
Predicted Functional Partners:
rhaR
Positive regulator for rhaRS operon; Activates expression of the rhaSR operon in response to L- rhamnose.
  
 
 0.945
melA
Alpha-galactosidase. (SW:AGAL_SALTY); Belongs to the glycosyl hydrolase 4 family.
 
  
 0.939
rhaS
Positive regulator for rhaBAD operon; Activates expression of the rhaBAD and rhaT operons.
 
 
 0.900
araC
Transcriptional regulator (AraC/XylS family) for ara operon; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose.
  
   
 0.883
STM4423
Similar to E. coli putative ARAC-type regulatory protein (AAC74766.1); Blastp hit to AAC74766.1 (303 aa), 27% identity in aa 38 - 283.
  
   0.744
STM0563
Putative transcriptional regulator (AraC/XylS family); Similar to E. coli putative ARAC-type regulatory protein (AAC73408.1); Blastp hit to AAC73408.1 (284 aa), 71% identity in aa 1 - 282.
  
     0.741
STM1671
Putative bacterial regulatory helix-turn-helix protein, araC family; Similar to E. coli putative ARAC-type regulatory protein (AAC73403.1); Blastp hit to AAC73403.1 (239 aa), 35% identity in aa 12 - 210.
  
     0.740
ydiP
Putative transcription regulator, AraC family; Similar to E. coli putative ARAC-type regulatory protein (AAC74766.1); Blastp hit to AAC74766.1 (303 aa), 80% identity in aa 1 - 292.
  
   0.736
soxS
Transcriptional activator of superoxide response regulon; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters (By similarity).
  
     0.721
marA
AraC/XylS family transcriptional activator of defense systems; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF.
  
   
 0.713
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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