Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
melAAlpha-galactosidase. (SW:AGAL_SALTY); Belongs to the glycosyl hydrolase 4 family. (451 aa)    
Predicted Functional Partners:
malZ
Similar to E. coli maltodextrin glucosidase (AAC73506.1); Blastp hit to AAC73506.1 (605 aa), 83% identity in aa 2 - 605; Belongs to the glycosyl hydrolase 13 family.
     
 0.940
nanH
Sialidase; Cleaves the terminal sialic acid (N-acetyl neuraminic acid) from carbohydrate chains in glycoproteins providing free sialic acid which can be used as carbon and energy sources. Sialidases have been suggested to be pathogenic factors in microbial infections.
     
 0.921
araA
L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose.
   
 
 0.904
yihR
Similar to E. coli putative aldose-1-epimerase (AAC76876.1); Blastp hit to AAC76876.1 (308 aa), 54% identity in aa 9 - 303.
   
 
  0.901
STM0035
Similar to E. coli putative sulfatase (AAC76701.1); Blastp hit to AAC76701.1 (497 aa), 26% identity in aa 2 - 420.
   
 
  0.900
galM
Galactose-1-epimerase (mutarotase); Converts alpha-aldose to the beta-anomer.
     
  0.900
STM3122
Similar to E. coli putative sulfatase (AAC74571.1); Blastp hit to AAC74571.1 (571 aa), 27% identity in aa 120 - 327, 43% identity in aa 322 - 358, 37% identity in aa 44 - 86, 31% identity in aa 435 - 471.
   
 
  0.900
melR
AraC/XylS family; similar to E. coli regulator of melibiose operon (AAC77079.1); Blastp hit to AAC77079.1 (302 aa), 88% identity in aa 4 - 302.
 
  
 0.879
melB
GPH family melibiose permease II; Responsible for melibiose transport. It is capable of using hydrogen, sodium, and lithium cations as coupling cations for cotransport, depending on the particular sugar transported (symport system); Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
  
  
 0.807
STM1252
Putative cytoplasmic protein.
   
  
 0.725
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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