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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ytfEPutative cell morphogenesis; Di-iron-containing protein involved in the repair of iron- sulfur clusters damaged by oxidative and nitrosative stress conditions. (220 aa)    
Predicted Functional Partners:
hmpA
Dihydropteridine reductase 2; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Belongs to the globin family. Two-domain flavohemoproteins subfamily.
  
  
 0.993
hcr
NADH oxidoreductase for hcp gene product; Similar to E. coli putative enzyme (AAC73959.1); Blastp hit to AAC73959.1 (322 aa), 90% identity in aa 1 - 322.
 
  
 0.949
yjeB
Putative negative regulator; Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity. Represses hmp expression under conditions of elevated intracellular iron concentrations, in the absence of nitric oxide.
  
  
 0.924
ygbA
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75774.1); Blastp hit to AAC75774.1 (117 aa), 86% identity in aa 1 - 114.
  
  
 0.902
yoaG
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC74866.1); Blastp hit to AAC74866.1 (60 aa), 96% identity in aa 1 - 60.
      
 0.893
STM1808
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC74867.1); Blastp hit to AAC74867.1 (119 aa), 42% identity in aa 2 - 113.
   
  
 0.882
hcp
Hybrid cluster protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
  
  
 0.831
norV
Putative flavoprotein; Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase; In the N-terminal section; belongs to the zinc metallo- hydrolase group 3 family.
  
  
 0.824
yeaR
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC74867.1); Blastp hit to AAC74867.1 (119 aa), 83% identity in aa 1 - 119.
   
  
 0.795
yggX
Putative cytoplasmic protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. Necessary to maintain high levels of aconitase under oxidative stress.
      
 0.699
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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