Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
iolGPutative dehydrogenase; Involved in the oxidation of myo-inositol (MI) to 2-keto-myo- inositol (2KMI or 2-inosose). (336 aa)    
Predicted Functional Partners:
iolE
Putative endonuclease; Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)- trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol). Belongs to the IolE/MocC family.
 
 
 0.999
STM4427
Putative endonuclease.
 
 
 0.995
STM4420
Putative inner membrane protein.
 
  
 0.994
STM4435
Putative cytoplasmic protein.
 
 0.984
STM4423
Similar to E. coli putative ARAC-type regulatory protein (AAC74766.1); Blastp hit to AAC74766.1 (303 aa), 27% identity in aa 38 - 283.
  
  
 0.982
STM4434
Similar to E. coli putative transport protein (AAC77235.1); Blastp hit to AAC77235.1 (425 aa), 22% identity in aa 167 - 417, 21% identity in aa 40 - 145.
   
  
 0.978
STM4433
Putative thiamine pyrophosphate-requiring enzyme; Oxidoreductase family; similar to E. coli putative virulence factor (AAC74152.1); Blastp hit to AAC74152.1 (307 aa), 29% identity in aa 1 - 188, 52% identity in aa 272 - 296.
  
 
 
0.956
srfJ
Activated by transcription factor SsrB; Similar to Homo sapiens lysosomal glucosyl ceramidase; SrfJ (gi|8347262); Belongs to the glycosyl hydrolase 30 family.
  
  
 0.938
STM4436
Putative endonuclease.
 
  
 0.918
suhB
Inositol monophosphatase; Similar to E. coli enhances synthesis of sigma32 in mutant; extragenic suppressor, may modulate RNAse III lethal action (AAC75586.1); Blastp hit to AAC75586.1 (267 aa), 97% identity in aa 1 - 267; Belongs to the inositol monophosphatase superfamily.
    
 0.904
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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