hsdM protein (Salmonella enterica Typhimurium)

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hsdM

DNA methylase M, host modification; Methylation of specific adenine residues; required for both restriction and modification activities (By similarity). The StySJI enzyme recognizes 5'-GAGN(6)GTRC-3'; Belongs to the N(4)/N(6)-methyltransferase family. (529 aa)

Predicted Functional Partners:

hsdS

0.999

hsdR

0.999

mrr

0.970

STM0839

0.895

mod

0.878

ydaL

0.859

rhuM

0.848

STM4491

0.816

STM4496

0.812

STM4495

0.805

Your Current Organism:

Salmonella enterica Typhimurium

NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
STM0839	hsdM	STM0839	STM4525	Putative inner membrane protein.	DNA methylase M, host modification; Methylation of specific adenine residues; required for both restriction and modification activities (By similarity). The StySJI enzyme recognizes 5'-GAGN(6)GTRC-3'; Belongs to the N(4)/N(6)-methyltransferase family.	0.895
STM4491	STM4495	STM4491	STM4495	Similar to E. coli DNA-binding, ATP-dependent protease La; heat shock K-protein (AAC73542.1); Blastp hit to AAC73542.1 (784 aa), 27% identity in aa 610 - 757, 26% identity in aa 193 - 259, 50% identity in aa 352 - 363.	Putative type II restriction enzyme, methylase subunit.	0.999
STM4491	STM4496	STM4491	STM4496	Similar to E. coli DNA-binding, ATP-dependent protease La; heat shock K-protein (AAC73542.1); Blastp hit to AAC73542.1 (784 aa), 27% identity in aa 610 - 757, 26% identity in aa 193 - 259, 50% identity in aa 352 - 363.	Putative ATPase involved in DNA repair.	0.999
STM4491	hsdM	STM4491	STM4525	Similar to E. coli DNA-binding, ATP-dependent protease La; heat shock K-protein (AAC73542.1); Blastp hit to AAC73542.1 (784 aa), 27% identity in aa 610 - 757, 26% identity in aa 193 - 259, 50% identity in aa 352 - 363.	DNA methylase M, host modification; Methylation of specific adenine residues; required for both restriction and modification activities (By similarity). The StySJI enzyme recognizes 5'-GAGN(6)GTRC-3'; Belongs to the N(4)/N(6)-methyltransferase family.	0.816
STM4491	hsdR	STM4491	STM4526	Similar to E. coli DNA-binding, ATP-dependent protease La; heat shock K-protein (AAC73542.1); Blastp hit to AAC73542.1 (784 aa), 27% identity in aa 610 - 757, 26% identity in aa 193 - 259, 50% identity in aa 352 - 363.	Host restriction; similar to E. coli host restriction; endonuclease R (AAC77306.1); Blastp hit to AAC77306.1 (1188 aa), 91% identity in aa 20 - 1188.	0.625
STM4491	hsdS	STM4491	STM4524	Similar to E. coli DNA-binding, ATP-dependent protease La; heat shock K-protein (AAC73542.1); Blastp hit to AAC73542.1 (784 aa), 27% identity in aa 610 - 757, 26% identity in aa 193 - 259, 50% identity in aa 352 - 363.	Specificity determinant for hsdM and hsdR; The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance M [...]	0.411
STM4491	mrr	STM4491	STM4527	Similar to E. coli DNA-binding, ATP-dependent protease La; heat shock K-protein (AAC73542.1); Blastp hit to AAC73542.1 (784 aa), 27% identity in aa 610 - 757, 26% identity in aa 193 - 259, 50% identity in aa 352 - 363.	Similar to E. coli restriction of methylated adenine (AAC77307.1); Blastp hit to AAC77307.1 (304 aa), 77% identity in aa 1 - 304.	0.682
STM4495	STM4491	STM4495	STM4491	Putative type II restriction enzyme, methylase subunit.	Similar to E. coli DNA-binding, ATP-dependent protease La; heat shock K-protein (AAC73542.1); Blastp hit to AAC73542.1 (784 aa), 27% identity in aa 610 - 757, 26% identity in aa 193 - 259, 50% identity in aa 352 - 363.	0.999
STM4495	STM4496	STM4495	STM4496	Putative type II restriction enzyme, methylase subunit.	Putative ATPase involved in DNA repair.	0.999
STM4495	hsdM	STM4495	STM4525	Putative type II restriction enzyme, methylase subunit.	DNA methylase M, host modification; Methylation of specific adenine residues; required for both restriction and modification activities (By similarity). The StySJI enzyme recognizes 5'-GAGN(6)GTRC-3'; Belongs to the N(4)/N(6)-methyltransferase family.	0.805
STM4495	hsdR	STM4495	STM4526	Putative type II restriction enzyme, methylase subunit.	Host restriction; similar to E. coli host restriction; endonuclease R (AAC77306.1); Blastp hit to AAC77306.1 (1188 aa), 91% identity in aa 20 - 1188.	0.721
STM4495	hsdS	STM4495	STM4524	Putative type II restriction enzyme, methylase subunit.	Specificity determinant for hsdM and hsdR; The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance M [...]	0.700
STM4495	mrr	STM4495	STM4527	Putative type II restriction enzyme, methylase subunit.	Similar to E. coli restriction of methylated adenine (AAC77307.1); Blastp hit to AAC77307.1 (304 aa), 77% identity in aa 1 - 304.	0.639
STM4496	STM4491	STM4496	STM4491	Putative ATPase involved in DNA repair.	Similar to E. coli DNA-binding, ATP-dependent protease La; heat shock K-protein (AAC73542.1); Blastp hit to AAC73542.1 (784 aa), 27% identity in aa 610 - 757, 26% identity in aa 193 - 259, 50% identity in aa 352 - 363.	0.999
STM4496	STM4495	STM4496	STM4495	Putative ATPase involved in DNA repair.	Putative type II restriction enzyme, methylase subunit.	0.999
STM4496	hsdM	STM4496	STM4525	Putative ATPase involved in DNA repair.	DNA methylase M, host modification; Methylation of specific adenine residues; required for both restriction and modification activities (By similarity). The StySJI enzyme recognizes 5'-GAGN(6)GTRC-3'; Belongs to the N(4)/N(6)-methyltransferase family.	0.812
STM4496	hsdR	STM4496	STM4526	Putative ATPase involved in DNA repair.	Host restriction; similar to E. coli host restriction; endonuclease R (AAC77306.1); Blastp hit to AAC77306.1 (1188 aa), 91% identity in aa 20 - 1188.	0.683
STM4496	hsdS	STM4496	STM4524	Putative ATPase involved in DNA repair.	Specificity determinant for hsdM and hsdR; The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance M [...]	0.500
STM4496	mrr	STM4496	STM4527	Putative ATPase involved in DNA repair.	Similar to E. coli restriction of methylated adenine (AAC77307.1); Blastp hit to AAC77307.1 (304 aa), 77% identity in aa 1 - 304.	0.433
hsdM	STM0839	STM4525	STM0839	DNA methylase M, host modification; Methylation of specific adenine residues; required for both restriction and modification activities (By similarity). The StySJI enzyme recognizes 5'-GAGN(6)GTRC-3'; Belongs to the N(4)/N(6)-methyltransferase family.	Putative inner membrane protein.	0.895

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