STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STM4529Putative cytoplasmic protein. (100 aa)    
Predicted Functional Partners:
STM4528
Putative inner membrane protein.
 
   0.995
STM1008
Gifsy-2 prophage protein; Hypothetical protein AAC26069.1 (gi|7467267).
      
 0.892
STM1760
Putative TPR repeat protein; Similar to E. coli orf, hypothetical protein (AAC73745.1); Blastp hit to AAC73745.1 (327 aa), 31% identity in aa 16 - 305, 33% identity in aa 29 - 273, 32% identity in aa 19 - 307, 33% identity in aa 47 - 320, 30-1073758628dentity in aa 22 - 312, 29% identity in aa 15 - 312, 34-1073758654dentity in aa 12 - 166.
      
 0.891
vapC
Putative nucleic acid-binding protein; Toxic component of a type II toxin-antitoxin (TA) system. A site-specific tRNA-(fMet) endonuclease, it cleaves both charged and uncharged tRNA-(fMet) between positions 38 and 39 at the anticodon stem-loop boundary. Does not cleave tRNA(Met), tRNA(Arg2), tRNA(His), tRNA(Leu), tRNA(Phe) tRNA(Thr1), tRNA(Tyr) or tRNA(Val). Overexpression in E.coli inhibits translation, leads to loss of cell growth and degradation of tRNA(fMet), these effects are neutralized by expression of cognate antitoxin VapB. Expression also activates translation initiation at c [...]
  
     0.633
STM4030
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC76117.1); Blastp hit to AAC76117.1 (138 aa), 45% identity in aa 19 - 138.
  
     0.533
vapB
Putative cytoplasmic protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli neutralizes the effect of cognate toxin VapC.
  
     0.499
citE
Similar to E. coli citrate lyase beta chain (acyl lyase subunit) (AAC73717.1); Blastp hit to AAC73717.1 (307 aa), 95% identity in aa 6 - 307; Belongs to the HpcH/HpaI aldolase family.
      
 0.459
citD
Citrate lyase acyl carrier protein (gamma chain); Covalent carrier of the coenzyme of citrate lyase.
      
 0.459
STM3117
Putative lactoylglutathione lyase; Is critically involved in promoting the replication of S.typhimurium cells inside host macrophages, suggesting a role in the establishment of bacterial colonization within macrophages. May be involved in the biosynthesis and modification of the peptidoglycan layer of the cell wall.
      
 0.459
STM3119
Putative monoamine oxidase; Similar to E. coli putative aldehyde dehydrogenase (AAC74469.1); Blastp hit to AAC74469.1 (681 aa), 29% identity in aa 530 - 661.
      
 0.459
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.