STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaCChromosome replication protein; Initiation and chain elongation; similar to E. coli chromosome replication; initiation and chain elongation (AAC77317.1); Blastp hit to AAC77317.1 (245 aa), 93% identity in aa 1 - 245. (245 aa)    
Predicted Functional Partners:
dnaT
Primosomal protein I; This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'.
  
 
 0.987
dnaB
Putative replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.
 
 0.985
dnaA
DNA replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. DnaA can inhibit its own gene expression as well as that of other genes (By similarity).
    
 
 0.926
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
  
 
 0.914
priB
Primosomal replication protein N; Binds single-stranded DNA at the primosome assembly site (PAS). During primosome assembly it facilitates the complex formation between PriA and DnaT; Belongs to the PriB family.
     
 0.901
priC
Similar to E. coli primosomal replication protein N'' (AAC73569.1); Blastp hit to AAC73569.1 (175 aa), 73% identity in aa 5 - 175.
      
 0.860
mioC
Similar to E. coli initiation of chromosome replication (AAC76765.1); Blastp hit to AAC76765.1 (147 aa), 87% identity in aa 1 - 147.
      
 0.852
yjjA
Similar to E. coli putative glycoprotein/receptor (AAC77316.1); Blastp hit to AAC77316.1 (165 aa), 68% identity in aa 3 - 165.
  
    0.706
yjjP
Similar to E. coli putative structural protein (AAC77320.1); Blastp hit to AAC77320.1 (277 aa), 90% identity in aa 19 - 277.
  
  
 0.705
yecA
Putative metal-binding protein; Similar to the C-terminal domain of SecA; similar to E. coli orf, hypothetical protein (AAC74978.1); Blastp hit to AAC74978.1 (221 aa), 81% identity in aa 1 - 221; Belongs to the UPF0149 family.
  
     0.650
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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