Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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STM4551Putative diguanylate cyclase/phosphodiesterase domain 1 containing protein; Similar to E. coli orf, hypothetical protein (AAC74110.1); Blastp hit to AAC74110.1 (452 aa), 41% identity in aa 274 - 444, 24% identity in aa 14 - 102. (354 aa)    
Predicted Functional Partners:
ylaB
Putative diguanylate cyclase/phosphodiesterase domain 2; Similar to E. coli orf, hypothetical protein (AAC73559.1); Blastp hit to AAC73559.1 (518 aa), 67% identity in aa 3 - 518.
  
 0.977
STM1827
Putative diguanylate cyclase/phosphodiesterase; Similar to E. coli orf, hypothetical protein (AAC74885.1); Blastp hit to AAC74885.1 (542 aa), 75% identity in aa 5 - 540.
 
  
 0.977
yhjK
Putative diguanylate cyclase/phosphodiesterase; Similar to E. coli orf, hypothetical protein (AAC76554.1); Blastp hit to AAC76554.1 (651 aa), 84% identity in aa 1 - 651.
 
 
 0.975
yjcC
Putative diguanylate cyclase/phosphodiesterase; Similar to E. coli orf, hypothetical protein (AAC77031.1); Blastp hit to AAC77031.1 (528 aa), 64% identity in aa 1 - 528.
  
 0.962
yhjH
Putative diguanylate cyclase/phosphodiesterase domain 3 containing protein; Similar to E. coli orf, hypothetical protein (AAC76550.1); Blastp hit to AAC76550.1 (256 aa), 79% identity in aa 2 - 256.
  
  
 0.944
STM0343
Putative diguanylate cyclase/phosphodiesterase domain 1; Similar to E. coli orf, hypothetical protein (AAC75237.1); Blastp hit to AAC75237.1 (518 aa), 31% identity in aa 10 - 512.
    0.931
STM1697
Putative diguanylate cyclase/phosphodiesterase domain 2; Similar to E. coli orf, hypothetical protein (AAC74777.1); Blastp hit to AAC74777.1 (237 aa), 29% identity in aa 17 - 189.
   
  
 0.879
ydiV
Putative diguanylate cyclase/phosphodiesterase domain 1; Acts as an anti-FlhC(2)FlhD(4) factor by binding to FlhD, decreasing its ability to bind DNA, and thus negatively regulates expression of flagellar class II operons, decreasing motility in nutrient-poor medium. Required for resistance to host phagocyte oxidase. Suppresses killing of macrophages, while promoting resistance to hydrogen peroxide. Data regarding c-di-GMP is controversial; suppresses bacterial c-di-GMP levels but neither synthesizes nor degrades c-di-GMP. Belongs to the YdiV family.
   
  
 0.875
rtn
Putative membrane protein involved in resistance to lambda and N4 phages; Similar to E. coli orf, hypothetical protein (AAC75237.1); Blastp hit to AAC75237.1 (518 aa), 70% identity in aa 1 - 518.
 
  
 0.874
yfeA
Diguanylate cyclase/phosphodiesterase domain 2; similar to E. coli orf, hypothetical protein (AAC75454.1); Blastp hit to AAC75454.1 (768 aa), 68% identity in aa 45 - 766.
  
  
 0.872
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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