Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
creBResponse regulator in two-component regulatory system with CreC; OmpR family; similar to E. coli catabolic regulation response regulator (AAC77351.1); Blastp hit to AAC77351.1 (229 aa), 83% identity in aa 1 - 229. (229 aa)    
Predicted Functional Partners:
creC
Sensory kinase (alternative) in two-component regulatory system with CreB (or alternatively PhoB); Senses catabolite repression; similar to E. coli catabolite repression sensor kinase for PhoB; alternative sensor for pho regulon (AAC77352.1); Blastp hit to AAC77352.1 (474 aa), 80% identity in aa 1 - 474.
 0.999
creA
Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC77350.1); Blastp hit to AAC77350.1 (157 aa), 89% identity in aa 1 - 157.
 
  
 0.946
creD
Similar to E. coli tolerance to colicin E2 (AAC77353.1); Blastp hit to AAC77353.1 (450 aa), 73% identity in aa 1 - 450.
 
  
 0.853
copS
Copper resistance; Member of a two-component regulatory system.
 
 
 0.850
baeS
Sensory kinase in two-component regulatoyr system wtih BaeR; Similar to E. coli sensor protein (for BaeR) (AAC75139.1); Blastp hit to AAC75139.1 (467 aa), 88% identity in aa 1 - 467.
 
 0.834
basS
Sensory kinase in two-component regulatory system with BasR; Member of the two-component regulatory system BasS/BasR. Autophosphorylates and activates BasR by phosphorylation. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well.
 
 
 0.819
phoR
Sensory kinase in two-component regulatory system with PhoB, regulates pho regulon; Similar to E. coli positive and negative sensor protein for pho regulon (AAC73503.1); Blastp hit to AAC73503.1 (431 aa), 90% identity in aa 1 - 431.
 
 0.817
STM0561
Sensor protein; Similar to E. coli putative 2-component sensor protein (AAC73671.1); Blastp hit to AAC73671.1 (480 aa), 74% identity in aa 375 - 479.
 
 
 0.816
arcB
Sensory histidine kinase in two-component regulatory system with ArcA; Senses redox conditions; similar to E. coli aerobic respiration sensor-response protein; histidine protein kinase/phosphatase, sensor for arcA (AAC76242.1); Blastp hit to AAC76242.1 (776 aa), 93% identity in aa 1 - 776.
 
 
 0.808
cpxA
Sensory kinase in two-component regulatory system with CpxR; Senses misfolded proteins in bacterial envelope; similar to E. coli probable sensor protein (histidine protein kinase), acting on arcA (AAC76893.1); Blastp hit to AAC76893.1 (457 aa), 96% identity in aa 1 - 457.
 
 0.804
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.