STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yjjYPutative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC77355.1); Blastp hit to AAC77355.1 (46 aa), 97% identity in aa 1 - 46. (46 aa)    
Predicted Functional Partners:
ycjG
Similar to E. coli putative muconate cycloisomerase I (AAC74407.1); Blastp hit to AAC74407.1 (335 aa), 85% identity in aa 15 - 335.
      
 0.899
yiaE
2-keto-D-gluconate reductase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
      
 0.771
lasT
Putative tRNA/tRNA methyltransferase; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
      
 0.700
arcA
Response regulator (OmpR family) in two-component regulatory system with ArcB (or CpxA); Regulates genes in aerobic pathways; similar to E. coli negative response regulator of genes in aerobic pathways, (sensors, ArcB and CpxA) (AAC77354.1); Blastp hit to AAC77354.1 (238 aa), 99% identity in aa 1 - 238.
  
    0.691
cdsA
Similar to E. coli CDP-diglyceride synthetase (AAC73286.1); Blastp hit to AAC73286.1 (249 aa), 95% identity in aa 1 - 249; Belongs to the CDS family.
   
  
 0.672
rnt
RNase T; Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.
      
 0.579
rimM
16S rRNA processing protein; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family.
   
  
 0.474
tyrR
Transcriptional regulatory protein TyrR; Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino acids (phenylalanine, tyrosine and tryptophan). These amino acids are suggested to act as co-effectors which bind to the TyrR protein to form an active regulatory protein. In most cases TyrR causes negative regulation, but positive effects on the tyrP gene have been observed at high phenylalani [...]
   
  
 0.456
ygfY
Putative cytoplasmic protein; An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.
   
  
 0.456
yobF
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC74894.1); Blastp hit to AAC74894.1 (47 aa), 93% identity in aa 1 - 47.
   
    0.448
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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