KRN98748.1 protein (Lactobacillus kimchiensis)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

KRN98748.1

Hypothetical protein. (150 aa)

Predicted Functional Partners:

KRN98747.1

0.973

proA

0.709

KRN99069.1

0.506

KRO00016.1

0.506

KRO00017.1

0.506

KRO00755.1

0.477

KRN99906.1

0.436

KRN97756.1

0.405

KRN97361.1

0.402

Your Current Organism:

Lactobacillus kimchiensis

NCBI taxonomy Id: 993692
Other names: DSM 24716, JCM 17702, KACC 15533, L. kimchiensis, Lactobacillus kimchiensis Kim et al. 2013, Lactobacillus sp. L133, strain L133

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRN97361.1	KRN98748.1	IV57_GL001724	IV57_GL000861	Adhesion exoprotein.	Hypothetical protein.	0.402
KRN97756.1	KRN98748.1	IV57_GL001598	IV57_GL000861	Response regulator.	Hypothetical protein.	0.405
KRN97756.1	KRN99069.1	IV57_GL001598	IV57_GL000493	Response regulator.	Hypothetical protein.	0.980
KRN97756.1	KRO00016.1	IV57_GL001598	IV57_GL002030	Response regulator.	Signal transduction protein.	0.874
KRN97756.1	KRO00017.1	IV57_GL001598	IV57_GL002031	Response regulator.	Signal transduction protein.	0.875
KRN97756.1	KRO00755.1	IV57_GL001598	IV57_GL000075	Response regulator.	Histidine protein kinase.	0.978
KRN98747.1	KRN98748.1	IV57_GL000860	IV57_GL000861	Hypothetical protein.	Hypothetical protein.	0.973
KRN98748.1	KRN97361.1	IV57_GL000861	IV57_GL001724	Hypothetical protein.	Adhesion exoprotein.	0.402
KRN98748.1	KRN97756.1	IV57_GL000861	IV57_GL001598	Hypothetical protein.	Response regulator.	0.405
KRN98748.1	KRN98747.1	IV57_GL000861	IV57_GL000860	Hypothetical protein.	Hypothetical protein.	0.973
KRN98748.1	KRN99069.1	IV57_GL000861	IV57_GL000493	Hypothetical protein.	Hypothetical protein.	0.506
KRN98748.1	KRN99906.1	IV57_GL000861	IV57_GL002238	Hypothetical protein.	Hypothetical protein.	0.436
KRN98748.1	KRO00016.1	IV57_GL000861	IV57_GL002030	Hypothetical protein.	Signal transduction protein.	0.506
KRN98748.1	KRO00017.1	IV57_GL000861	IV57_GL002031	Hypothetical protein.	Signal transduction protein.	0.506
KRN98748.1	KRO00755.1	IV57_GL000861	IV57_GL000075	Hypothetical protein.	Histidine protein kinase.	0.477
KRN98748.1	proA	IV57_GL000861	IV57_GL001217	Hypothetical protein.	Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.	0.709
KRN99069.1	KRN97756.1	IV57_GL000493	IV57_GL001598	Hypothetical protein.	Response regulator.	0.980
KRN99069.1	KRN98748.1	IV57_GL000493	IV57_GL000861	Hypothetical protein.	Hypothetical protein.	0.506
KRN99069.1	KRO00755.1	IV57_GL000493	IV57_GL000075	Hypothetical protein.	Histidine protein kinase.	0.602
KRN99906.1	KRN98748.1	IV57_GL002238	IV57_GL000861	Hypothetical protein.	Hypothetical protein.	0.436

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.95

expected number of edges:

31

PPI enrichment p-value:

0.0955

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031929

TOR signaling

5 of 15

3.5

6.88

3.34e-13

GO:0006657

CDP-choline pathway

4 of 25

3.18

4.61

3.84e-09

GO:0006650

Glycerophospholipid metabolic process

6 of 568

2.0

3.49

1.45e-08

GO:0010506

Regulation of autophagy

3 of 24

3.08

3.19

1.55e-06

GO:0030307

Positive regulation of cell growth

3 of 32

2.95

3.04

2.78e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031210

Phosphatidylcholine binding

2 of 10

3.28

1.67

0.00098

GO:0004305

Ethanolamine kinase activity

2 of 12

3.2

1.67

0.00098

GO:0004105

Choline-phosphate cytidylyltransferase activity

2 of 7

3.44

1.67

0.00098

GO:0004103

Choline kinase activity

2 of 9

3.33

1.67

0.00098

GO:0008889

Glycerophosphodiester phosphodiesterase activity

2 of 38

2.7

1.41

0.0027

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031931

TORC1 complex

5 of 9

3.72

7.8

7.97e-15

GO:0031932

TORC2 complex

2 of 6

3.5

2.26

8.55e-05

GO:0110165

Cellular anatomical entity

9 of 19699

0.64

0.5

0.0020

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17782

TOR complex, and Choline/ethanolamine kinase

5 of 13

3.57

6.76

5.71e-13

CL:106944

Phosphatidylcholine biosynthetic process

4 of 14

3.44

5.31

2.35e-10

CL:17798

TOR complex, and Choline/ethanolamine kinase

2 of 5

3.58

2.13

0.00015

CL:17784

TOR complex, and Choline/ethanolamine kinase

2 of 5

3.58

2.13

0.00015

CL:106961

Phosphoethanolamine N-methyltransferase, and Choline-phosphate cytidylyltransferase activity

2 of 5

3.58

2.13

0.00015

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04136

Autophagy - other

5 of 116

2.61

5.11

1.34e-10

map00564

Glycerophospholipid metabolism

6 of 919

1.79

3.09

1.60e-08

map00440

Phosphonate and phosphinate metabolism

2 of 29

2.82

1.98

0.00024

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-166208

mTORC1-mediated signalling

5 of 10

3.68

7.71

1.14e-14

MAP-8943724

Regulation of PTEN gene transcription

5 of 32

3.17

6.57

8.26e-13

MAP-380972

Energy dependent regulation of mTOR by LKB1-AMPK

5 of 90

2.72

5.32

7.30e-11

MAP-165159

MTOR signalling

5 of 95

2.7

5.31

7.30e-11

MAP-9711097

Cellular response to starvation

5 of 109

2.64

5.17

1.11e-10

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031931

TORC1 complex

5 of 18

3.42

6.93

2.42e-13

GOCC:0031932

TORC2 complex

2 of 15

3.1

1.73

0.00075

GOCC:0110165

Cellular anatomical entity

6 of 8339

0.84

0.48

0.0339

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0853

WD repeat

5 of 711

1.83

2.47

2.30e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01633

Choline/ethanolamine kinase

2 of 12

3.2

1.4

0.0030

PF01467

Cytidylyltransferase-like

2 of 25

2.88

1.24

0.0057

PF03009

Glycerophosphoryl diester phosphodiesterase family

2 of 38

2.7

1.14

0.0085

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029347

Raptor, N-terminal CASPase-like domain

3 of 3

3.98

3.78

1.61e-07

IPR004083

Regulatory associated protein of TOR

3 of 3

3.98

3.78

1.61e-07

IPR037588

Target of rapamycin complex subunit LST8

2 of 2

3.98

2.21

0.00011

IPR001680

WD40 repeat

5 of 765

1.8

2.04

2.92e-05

IPR015943

WD40/YVTN repeat-like-containing domain superfamily

5 of 876

1.74

1.93

4.28e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01302

Raptor N-terminal CASPase like domain

3 of 3

3.98

4.43

1.12e-08

SM00320

WD40 repeats

5 of 771

1.79

2.38

3.18e-06

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