STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACBD3Acyl-CoA binding domain containing 3. (490 aa)    
Predicted Functional Partners:
PI4KB
Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family.
    
 
 0.941
OSBP
Oxysterol-binding protein; Belongs to the OSBP family.
   
  
 0.909
GOLGB1
Golgin B1.
    
 0.892
ARF1
ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family.
      
 0.874
PPM1H
Protein phosphatase, Mg2+/Mn2+ dependent 1H.
    
 
 0.790
GBF1
Golgi brefeldin A resistant guanine nucleotide exchange factor 1.
      
 0.770
PI4K2A
PI3K/PI4K domain-containing protein.
      
 0.767
VDAC1
Uncharacterized protein.
      
 0.738
TSPO
Translocator protein; Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides.
      
 0.732
W5QE83_SHEEP
Uncharacterized protein.
    
 
 0.710
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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