node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGT | BDKRB2 | ENSOARP00000003247 | ENSOARP00000017170 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. | 0.958 |
AGT | EDN1 | ENSOARP00000003247 | ENSOARP00000015104 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 0.907 |
AGT | EDNRA | ENSOARP00000003247 | ENSOARP00000008763 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). | 0.980 |
AGT | EDNRB | ENSOARP00000003247 | ENSOARP00000000136 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. | 0.965 |
AGT | F2 | ENSOARP00000003247 | ENSOARP00000004316 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | Uncharacterized protein; Belongs to the peptidase S1 family. | 0.605 |
AGT | GNA11 | ENSOARP00000003247 | ENSOARP00000014006 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | G protein subunit alpha 11. | 0.459 |
AGT | GNAQ | ENSOARP00000003247 | ENSOARP00000013278 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | G protein subunit alpha q. | 0.459 |
AGT | KNG1 | ENSOARP00000003247 | ENSOARP00000022046 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | Kininogen 1. | 0.488 |
AGT | W5Q2Y4_SHEEP | ENSOARP00000003247 | ENSOARP00000017072 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | Uncharacterized protein. | 0.443 |
BDKRB2 | AGT | ENSOARP00000017170 | ENSOARP00000003247 | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | 0.958 |
BDKRB2 | EDN1 | ENSOARP00000017170 | ENSOARP00000015104 | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 0.469 |
BDKRB2 | EDNRA | ENSOARP00000017170 | ENSOARP00000008763 | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. | Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). | 0.930 |
BDKRB2 | EDNRB | ENSOARP00000017170 | ENSOARP00000000136 | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. | Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. | 0.929 |
BDKRB2 | F2 | ENSOARP00000017170 | ENSOARP00000004316 | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. | Uncharacterized protein; Belongs to the peptidase S1 family. | 0.938 |
BDKRB2 | GNA11 | ENSOARP00000017170 | ENSOARP00000014006 | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. | G protein subunit alpha 11. | 0.933 |
BDKRB2 | GNAQ | ENSOARP00000017170 | ENSOARP00000013278 | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. | G protein subunit alpha q. | 0.933 |
BDKRB2 | KNG1 | ENSOARP00000017170 | ENSOARP00000022046 | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. | Kininogen 1. | 0.980 |
BDKRB2 | W5Q2Y4_SHEEP | ENSOARP00000017170 | ENSOARP00000017072 | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. | Uncharacterized protein. | 0.433 |
EDN1 | AGT | ENSOARP00000015104 | ENSOARP00000003247 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | 0.907 |
EDN1 | BDKRB2 | ENSOARP00000015104 | ENSOARP00000017170 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. | 0.469 |