STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NLRP12NLR family pyrin domain containing 12. (1055 aa)    
Predicted Functional Partners:
PYCARD
PYD and CARD domain containing.
   
 0.969
RELA
RELA proto-oncogene, NF-kB subunit.
   
 0.915
NFKB1
Nuclear factor kappa B subunit 1.
   
 
 0.910
NLRC4
NLR family CARD domain containing 4.
   
 
 0.859
MEFV
MEFV innate immuity regulator, pyrin.
   
0.669
HNMT
Histamine N-methyltransferase.
      
 0.664
LOC101117013
Uncharacterized protein; Belongs to the peptidase C14A family.
   
 0.637
CACNG7
Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
   
  
 0.623
NLRP1
NLR family pyrin domain containing 1.
    
 
0.618
CLEC2L
C-type lectin domain family 2 member L.
      
 0.588
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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