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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FOXB1Forkhead box B1. (304 aa)    
Predicted Functional Partners:
SOX5
SRY-box transcription factor 5.
      
 0.765
PRDM16
PR/SET domain 16.
      
 0.643
ZNF263
Uncharacterized protein.
      
 0.627
FAM81B
Family with sequence similarity 81 member B.
      
 0.601
PPM1F
Protein phosphatase, Mg2+/Mn2+ dependent 1F.
   
  
 0.596
SOX11
Transcription factor SOX.
   
  
 0.586
THNSL2
Threonine synthase like 2.
      
 0.585
HOMEZ
Homeobox and leucine zipper encoding.
      
 0.581
LPGAT1
Lysophosphatidylglycerol acyltransferase 1.
      
 0.572
PKNOX2
PBX/knotted 1 homeobox 2.
      
 0.538
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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